Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can)

Almquist, MartinLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups (författare)

Objective To investigate metabolic factors and their possible impact on risk of thyroid cancer. Methods A prospective cohort study was conducted based on seven population-based cohorts in Norway, Austria, and Sweden, in the Metabolic syndrome and Cancer project (Me-Can). Altogether 578,700 men and women with a mean age of 44.0 years at baseline were followed for on average 12.0 years. Relative risk of incident thyroid cancer was assessed by levels of BMI, blood pressure, and blood levels of glucose, cholesterol, triglycerides, and by a combined metabolic syndrome (MetS) score. Risk estimates were investigated for quintiles, and a z score distribution of exposures was analyzed using Cox proportional hazards regression. Results During follow-up, 255 women and 133 men were diagnosed with thyroid cancer. In women, there was an inverse association between glucose and thyroid cancer risk, with adjusted RR: 95% CI was 0.61 (0.41–0.90), p trend = 0.02 in the fifth versus the first quintile, and a positive association between BMI and thyroid cancer risk with a significant trend over quintiles. There was no association between the other metabolic factors, single or combined (Met-S), and thyroid cancer. Conclusion In women, BMI was positively, while blood glucose levels were inversely, associated with thyroid cancer.

Johansen, DortheLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kirm-djo (författare)
Björge, Tone (författare)
Ulmer, Hanno (författare)
Lindkvist, BjörnLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-bl0 (författare)
Stocks, TanjaUmeå University,Umeå universitet,Urologi och andrologi(Swepub:lu)med-tss (författare)
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (författare)
Engeland, Anders (författare)
Rapp, Kilian (författare)
Jonsson, HåkanUmeå universitet,Onkologi(Swepub:umu)hojo0001 (författare)
Selmer, Randi (författare)
Diem, Guenter (författare)
Häggström, ChristelUmeå universitet,Urologi och andrologi(Swepub:umu)chlham02 (författare)
Tretli, Steinar (författare)
Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003 (författare)
Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma (författare)
KirurgiForskargrupper vid Lunds universitet (creator_code:org_t)

Av författaren/redakt...: Almquist, Martin; Johansen, Dorthe; Björge, Tone; Ulmer, Hanno; Lindkvist, Björn; Stocks, Tanja; visa fler...; Hallmans, Göran; Engeland, Anders; Rapp, Kilian; Jonsson, Håkan; Selmer, Randi; Diem, Guenter; Häggström, Chris ...; Tretli, Steinar; Stattin, Pär; Manjer, Jonas; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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