WFRF:(Lindström Åke)
Sökning: WFRF:(Lindström Åke) > (2005-2009) > Targeting malignant...
Targeting malignant glioma cells in vitro using platelet-derived growth factor AA-based conjugates
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- Dahlström Wester, Maria (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Wasteson, Åke (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Lindström, Annelie (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
- (creator_code:org_t)
- 2009-05
- 2009
- Engelska.
- Ingår i: Journal of drug targeting. - : Informa UK Limited. - 1029-2330 .- 1061-186X. ; , s. 1-10
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Glioblastoma multiforme (GBM) is an unusually aggressive brain tumor; it is also highly heterogeneous. Poor prognosis and a median survival of less than 1 year, using conventional treatment, calls for development of new treatment strategies. Overexpression and/or amplification of platelet-derived growth factor alpha receptors (PDGFalphaRs) in GBM might act as potential targets for a novel therapeutic approach. In this study, conjugates based on PDGFAA-ligand and dextran, of different sizes (10 and 40 kDa dextran), were prepared and investigated regarding targeting properties in vitro. Three human malignant glioma cell lines, U343MGa31L, U343MGaCl2:6, and U563MG, were used because of their previously reported differences in receptor expression and behavior. PDGFAA-based 10 kDa dextran iodine-125 radiolabeled conjugates showed the most favorable properties according to results achieved in accumulation, retention, and localization of cell-associated radioactivity. In comparison with dextran-(125)I-tyrosine delivered radioactivity, the PDGFAA-based dextran conjugates confirm the potential of receptor targeting.
Nyckelord
- Conjugate
- dextran
- glioblastoma multiforme
- PDGFAA
- PDGF receptors
- targeting
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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