Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs : Focus on Topiramate, Levetiracetam, and Perampanel

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Fältnamn	Indikatorer	Metadata
000		03953naa a2200361 4500
001		oai:lup.lub.lu.se:3eb16509-5252-41f2-aca5-33909fb423cc
003		SwePub
008		190110s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/3eb16509-5252-41f2-aca5-33909fb423cc2 URI
024	7	a https://doi.org/10.1155/2018/20640272 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a for2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Hansen, Cerine C.u Norwegian University of Science and Technology4 aut
245	1 0	a Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs : Focus on Topiramate, Levetiracetam, and Perampanel
264	1	b Hindawi Limited,c 2018
300		a 18 s.
520		a Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk factors, and the underlying mechanisms of AB induced by AEDs may help to facilitate management and reduce the risk of such side effects. The exact incidence of AB as an adverse effect of AEDs is difficult to estimate, but frequencies up to 16% have been reported. Primarily, levetiracetam (LEV), perampanel (PER), and topiramate (TPM), which have diverse mechanisms of action, have been associated with AB. Currently, there is no evidence for a specific pharmacological mechanism solely explaining the increased incidence of AB with LEV, PER, and TPM. Serotonin (5-HT) and GABA, and particularly glutamate (via the AMPA receptor), seem to play key roles. Other mechanisms involve hormones, epigenetics, and "alternative psychosis" and related phenomena. Increased individual susceptibility due to an underlying neurological and/or a mental health disorder may further explain why people with epilepsy are at an increased risk of AB when using AEDs. Remarkably, AB may occur with a delay of weeks or months after start of treatment. Information to patients, relatives, and caregivers, as well as sufficient clinical follow-up, is crucial, and there is a need for further research to understand the complex relationship between AED mechanisms of action and the induction/worsening of AB.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Ljung, Hannau Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-hlj
700	1	a Brodtkorb, Eylertu St. Olav’s University Hospital,Norwegian University of Science and Technology4 aut
700	1	a Reimers, Arneu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)ar4172re
710	2	a Norwegian University of Science and Technologyb Neurologi, Lund4 org
773	0	t Behavioural Neurologyd : Hindawi Limitedg 2018q 2018x 0953-4180x 1875-8584
856	4	u http://dx.doi.org/10.1155/2018/2064027x freey FULLTEXT
856	4	u https://doi.org/10.1155/2018/2064027
856	4 8	u https://lup.lub.lu.se/record/3eb16509-5252-41f2-aca5-33909fb423cc
856	4 8	u https://doi.org/10.1155/2018/2064027

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