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- Löfström, Bjorn (författare)
Expression of APRIL in Diffuse Large B Cell Lymphomas from Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
- 2011-07-01
- The Journal of Rheumatology,2011
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-160197
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160197URI
- https://doi.org/10.3899/jrheum.101190DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123279608URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Objective: Patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have an increased risk of diffuse large B cell lymphoma (DLBCL). The cytokine A PRoliferating-Inducing Ligand (APRIL) is strongly expressed in DLBCL in the general population and is detected in high concentrations in sera from subgroups of patients with RA and SLE. To investigate a possible association between APRIL and DLBCL in RA and SLE, we examined APRIL expression in lymphoma biopsies from patients with RA and SLE and from DLBCL patients without inflammatory disease.Methods: Lymphoma tissue from 95 RA, 12 SLE, and 63 comparator DLBCL cases were stained with anti-APRIL antibodies (Aprily-2). The percentage of positively stained cells of the comparator cases were divided into quartiles (1-4, where 4 = most stained) and compared with the results for the RA and SLE lymphomas. APRIL expression was correlated to clinical variables.Results: The odds ratio for high expression of APRIL (quartiles 3 and 4) was elevated in the SLE DLBCL (OR 23.6, 95% CI 2.4-231.2), but not in the RA DLBCL (OR 0.8, 95% CI 0.3-2.0). RA patients in quartile 4 had higher cumulated RA disease activity than those in quartile I (p = 0.013). Epstein-Barr virus in the lymphoma tissue was associated with high APRIL expression (p = 0.009).Conclusion: The high expression of APRIL in DLBCL in SLE and in an RA subset might indicate an association between APRIL and lymphoma in these subsets of rheumatic diseases, but could also reflect a dysregulation of APRIL per se in these patient groups.
Ämnesord och genrebeteckningar
- Systemic Lupus Erythematosus
- Rheumatoid Arthritis
- Malignant Lymphoma
- Diffuse Large B Cell Lymphoma
- A Proliferating-inducing Ligand
- April
- Epstein-Barr Virus
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Backlin, CarinUppsala universitet,Institutionen för medicinska vetenskaper (författare)
- Pettersson, Tom (författare)
- Lundberg, Ingrid E.Karolinska Institutet (författare)
- Baecklund, EvaUppsala universitet,Reumatologi(Swepub:uu)evaba786 (författare)
- Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Rheumatology: The Journal of Rheumatology38:9, s. 1891-18970315-162X1499-2752
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- Journal of Rheumatology (Sök värdpublikationen i LIBRIS)
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- Av författaren/redakt...
- Löfström, Bjorn
- Backlin, Carin
- Pettersson, Tom
- Lundberg, Ingrid ...
- Baecklund, Eva
- Artiklar i publikationen
- Journal of Rheum ...
- Av lärosätet
- Uppsala universitet
- Karolinska Institutet
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