The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract

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Fältnamn	Indikatorer	Metadata
000		04610naa a2200925 4500
001		oai:DiVA.org:umu-116966
003		SwePub
008		160216s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1169662 URI
024	7	a https://doi.org/10.1371/journal.pone.01176392 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Delahaye-Sourdeix, Manon4 aut
245	1 0	a The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
264		c 2015-03-20
264	1	b Public library science,c 2015
338		a print2 rdacarrier
520		a Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Oliver, Javier4 aut
700	1	a Timofeeva, Maria N4 aut
700	1	a Gaborieau, Valérie4 aut
700	1	a Johansson, Mattiasu Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France4 aut0 (Swepub:umu)masmas97
700	1	a Chabrier, Amélie4 aut
700	1	a Wozniak, Magdalena B4 aut
700	1	a Brenner, Darren R4 aut
700	1	a Vallée, Maxime P4 aut
700	1	a Anantharaman, Devasena4 aut
700	1	a Lagiou, Pagona4 aut
700	1	a Holcátová, Ivana4 aut
700	1	a Richiardi, Lorenzo4 aut
700	1	a Kjaerheim, Kristina4 aut
700	1	a Agudo, Antonio4 aut
700	1	a Castellsagué, Xavier4 aut
700	1	a Macfarlane, Tatiana V4 aut
700	1	a Barzan, Luigi4 aut
700	1	a Canova, Cristina4 aut
700	1	a Thakker, Nalin S4 aut
700	1	a Conway, David I4 aut
700	1	a Znaor, Ariana4 aut
700	1	a Healy, Claire M4 aut
700	1	a Ahrens, Wolfgang4 aut
700	1	a Zaridze, David4 aut
700	1	a Szeszenia-Dabrowska, Neonilia4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Fabianova, Eleonora4 aut
700	1	a Mates, Ioan Nicolae4 aut
700	1	a Bencko, Vladimir4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Curado, Maria Paula4 aut
700	1	a Koifman, Sergio4 aut
700	1	a Menezes, Ana4 aut
700	1	a Wünsch-Filho, Victor4 aut
700	1	a Eluf-Neto, José4 aut
700	1	a Boffetta, Paolo4 aut
700	1	a Garrote, Leticia Fernández4 aut
700	1	a Serraino, Diego4 aut
700	1	a Lener, Marcin4 aut
700	1	a Jaworowska, Ewa4 aut
700	1	a Lubiński, Jan4 aut
700	1	a Boccia, Stefania4 aut
700	1	a Rajkumar, Thangarajan4 aut
700	1	a Samant, Tanuja A4 aut
700	1	a Mahimkar, Manoj B4 aut
700	1	a Matsuo, Keitaro4 aut
700	1	a Franceschi, Silvia4 aut
700	1	a Byrnes, Graham4 aut
700	1	a Brennan, Paul4 aut
700	1	a McKay, James D4 aut
710	2	a Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France4 org
773	0	t PLOS ONEd : Public library scienceg 10:3q 10:3x 1932-6203
856	4	u https://doi.org/10.1371/journal.pone.0117639y Fulltext
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117639&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-116966
856	4 8	u https://doi.org/10.1371/journal.pone.0117639

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Av författaren/redakt...: Delahaye-Sourdei ...; Oliver, Javier; Timofeeva, Maria ...; Gaborieau, Valér ...; Johansson, Matti ...; Chabrier, Amélie; visa fler...; Wozniak, Magdale ...; Brenner, Darren ...; Vallée, Maxime P; Anantharaman, De ...; Lagiou, Pagona; Holcátová, Ivana; Richiardi, Loren ...; Kjaerheim, Krist ...; Agudo, Antonio; Castellsagué, Xa ...; Macfarlane, Tati ...; Barzan, Luigi; Canova, Cristina; Thakker, Nalin S; Conway, David I; Znaor, Ariana; Healy, Claire M; Ahrens, Wolfgang; Zaridze, David; Szeszenia-Dabrow ...; Lissowska, Jolan ...; Fabianova, Eleon ...; Mates, Ioan Nico ...; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Curado, Maria Pa ...; Koifman, Sergio; Menezes, Ana; Wünsch-Filho, Vi ...; Eluf-Neto, José; Boffetta, Paolo; Garrote, Leticia ...; Serraino, Diego; Lener, Marcin; Jaworowska, Ewa; Lubiński, Jan; Boccia, Stefania; Rajkumar, Thanga ...; Samant, Tanuja A; Mahimkar, Manoj ...; Matsuo, Keitaro; Franceschi, Silv ...; Byrnes, Graham; Brennan, Paul; McKay, James D; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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