Sökning: WFRF:(Maehle L.) > (2010-2014) > Chromosomes 4 and 8...
Fältnamn | Indikatorer | Metadata |
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000 | 05492naa a2201021 4500 | |
001 | oai:DiVA.org:umu-52366 | |
003 | SwePub | |
008 | 120220s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:123955487 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-523662 URI |
024 | 7 | a https://doi.org/10.1002/pros.214432 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1239554872 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lu, Lingyi4 aut |
245 | 1 0 | a Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG |
264 | c 2011-07-11 | |
264 | 1 | b Wiley,c 2012 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD?=?1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS. In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS. Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37cM interval on 4q13-25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD cores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology. CONCLUSIONS. These results will be useful in prioritizing future susceptibility gene discovery efforts in thiscommon cancer. Prostate 72: 410-426, 2012. (C) 2011 Wiley Periodicals, Inc. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Cancel-Tassin, Geraldine4 aut |
700 | 1 | a Valeri, Antoine4 aut |
700 | 1 | a Cussenot, Olivier4 aut |
700 | 1 | a Lange, Ethan M.4 aut |
700 | 1 | a Cooney, Kathleen A.4 aut |
700 | 1 | a Farnham, James M.4 aut |
700 | 1 | a Camp, Nicola J.4 aut |
700 | 1 | a Cannon-Albright, Lisa A.4 aut |
700 | 1 | a Tammela, Teuvo L. J.4 aut |
700 | 1 | a Schleutker, Johanna4 aut |
700 | 1 | a Hoegel, Josef4 aut |
700 | 1 | a Herkommer, Kathleen4 aut |
700 | 1 | a Maier, Christiane4 aut |
700 | 1 | a Vogel, Walther4 aut |
700 | 1 | a Wiklund, Fredriku Karolinska Institutet4 aut |
700 | 1 | a Emanuelsson, Monicau Umeå universitet,Onkologi4 aut0 (Swepub:umu)moem0001 |
700 | 1 | a Groenberg, Henriku Karolinska Institutet4 aut |
700 | 1 | a Wiley, Kathleen E.4 aut |
700 | 1 | a Isaacs, Sarah D.4 aut |
700 | 1 | a Walsh, Patrick C.4 aut |
700 | 1 | a Helfand, Brian T.4 aut |
700 | 1 | a Kan, Donghui4 aut |
700 | 1 | a Catalona, William J.4 aut |
700 | 1 | a Stanford, Janet L.4 aut |
700 | 1 | a FitzGerald, Liesel M.4 aut |
700 | 1 | a Johanneson, Bo4 aut |
700 | 1 | a Deutsch, Kerry4 aut |
700 | 1 | a McIntosh, Laura4 aut |
700 | 1 | a Ostrander, Elaine A.4 aut |
700 | 1 | a Thibodeau, Stephen N.4 aut |
700 | 1 | a McDonnell, Shannon K.4 aut |
700 | 1 | a Hebbring, Scott4 aut |
700 | 1 | a Schaid, Daniel J.4 aut |
700 | 1 | a Whittemore, Alice S.4 aut |
700 | 1 | a Oakley-Girvan, Ingrid4 aut |
700 | 1 | a Hsieh, Chih-Lin4 aut |
700 | 1 | a Powell, Isaac4 aut |
700 | 1 | a Bailey-Wilson, Joan E.4 aut |
700 | 1 | a Cropp, Cheryl D.4 aut |
700 | 1 | a Simpson, Claire4 aut |
700 | 1 | a Carpten, John D.4 aut |
700 | 1 | a Seminara, Daniela4 aut |
700 | 1 | a Zheng, S. Lilly4 aut |
700 | 1 | a Xu, Jianfen4 aut |
700 | 1 | a Giles, Graham G.4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Hopper, John L.4 aut |
700 | 1 | a English, Dallas R.4 aut |
700 | 1 | a Foulkes, William D.4 aut |
700 | 1 | a Maehle, Lovise4 aut |
700 | 1 | a Moller, Pal4 aut |
700 | 1 | a Badzioch, Michael D.4 aut |
700 | 1 | a Edwards, Steve4 aut |
700 | 1 | a Guy, Michelle4 aut |
700 | 1 | a Eeles, Ros4 aut |
700 | 1 | a Easton, Douglas4 aut |
700 | 1 | a Isaacs, William B.4 aut |
710 | 2 | a Karolinska Institutetb Onkologi4 org |
773 | 0 | t The Prostated : Wileyg 72:4, s. 410-426q 72:4<410-426x 0270-4137x 1097-0045 |
856 | 4 | u https://europepmc.org/articles/pmc3568777?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52366 |
856 | 4 8 | u https://doi.org/10.1002/pros.21443 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:123955487 |
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