Wild-type Leishmania donovani promastigotes block maturation, increase integrin expression and inhibit detachment of human monocyte-derived dendritic cells - The influence of phosphoglycans

Tejle, Katarina, 1945- (författare): Linköpings universitet,Hälsouniversitetet,Medicinsk mikrobiologi

Lindroth, Margaretha, 1950- (författare): Linköpings universitet,Hälsouniversitetet,Medicinsk mikrobiologi

Magnusson, Karl-Eric, 1946- (författare): Linköpings universitet,Hälsouniversitetet,Medicinsk mikrobiologi

Rasmusson, Birgitta, 1963- (författare): Linköpings universitet,Hälsouniversitetet,Medicinsk mikrobiologi

(creator_code:org_t)

Oxford University Press (OUP), 2008
2008
Engelska.
Ingår i: FEMS Microbiology Letters. - : Oxford University Press (OUP). - 0378-1097 .- 1574-6968. ; 279:1, s. 92-102

Relaterad länk:: http://www.ncbi.nlm....; visa fler...; https://academic.oup...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

The protective immune response against the parasite, including the role of dendritic cells (DC) in the course of infection, plays a fundamental role. This study shows that wild-type (WT) Leishmania promastigotes and specifically the phosphoglycans family of virulence-associated antigens inhibit human monocyte-derived dendritic cells (MoDC) maturation and detachment to distinct surfaces. Immature phagocytosis of Leishmania donovani promastigotes by immature MoDC results in the increased expression of CD11b and CD51, and inhibition of cell detachment to distinct surfaces, which was dependent on the presence of phosphoglycans. These findings demonstrate that phosphoglycans of WT L. donovani might also inhibit human DC migration to lymphoid organs. © 2007 Federation of European Microbiological Societies.

Av författaren/redakt...: Tejle, Katarina, ...; Lindroth, Margar ...; Magnusson, Karl- ...; Rasmusson, Birgi ...

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