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Intensive treatment...
Intensive treatment and stem cell transplantation in chronic myelogenous leukemia : long-term follow-up
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- Simonsson, Bengt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Blodsjukdomar
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- Öberg, Gunnar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Blodsjukdomar
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Björeman, Mats (author)
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- Björkholm, Magnus (author)
- Karolinska Institutet
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Carneskog, Jan (author)
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- Karlsson, Karin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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- Gahrton, Gösta (author)
- Karolinska Institutet
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Grimfors, Gunnar (author)
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- Hast, Robert (author)
- Karolinska Institutet
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Karle, Hans (author)
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Linder, Olle (author)
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- Ljungman, Per (author)
- Karolinska Institutet
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Nielsen, Johan L (author)
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Nilsson, Jonas (author)
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- Löfvenberg, Eva (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Malm, Claes, 1945- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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Olsson, Karin (author)
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- Olsson-Strömberg, Ulla (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Blodsjukdomar
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- Paul, Christer (author)
- Karolinska Institutet
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- Stenke, Leif (author)
- Karolinska Institutet
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Stentoft, Jesper (author)
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- Turesson, Ingemar (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Udén, Ann-Marie (author)
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- Wahlin, Anders (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Vilén, Lars (author)
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Weis-Bjerrum, Ole (author)
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(creator_code:org_t)
- 2005-05-02
- 2005
- English.
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In: Acta Haematologica. - : S. Karger AG. - 0001-5792 .- 1421-9662. ; 113:3, s. 155-162
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Abstract
Subject headings
Close
- In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT. Patients who had an HLA-identical sibling donor and no contraindication went for an allogeneic SCT (related donor, RD). After diagnosis, patients not allotransplanted received HU and IFN to keep WBC and platelet counts low. After 6 months patients with Ph-positive cells still present in the bone marrow received 1–3 courses of intensive chemotherapy. Those who became Ph-negative after IFN + HU or after 1–3 chemotherapy courses underwent autologous SCT. Some patients with poor cytogenetic response were allotransplanted with an unrelated donor (URD). IFN + HU reduced the percentage of Ph-positive metaphases in 56% of patients, and 1 patient became Ph-negative. After one or two intensive cytotherapies 86 and 88% had a Ph reduction, and 34 and 40% became Ph-negative, respectively. In patients receiving a third intensive chemotherapy 92% achieved a Ph reduction and 8% became Ph-negative. The median survival after auto-SCT (n = 46) was 7.5 years. The chance of remaining Ph-negative for up to 10 years after autologous SCT was around 20%. The overall survival for allo-SCT RD (n = 91) and URD (n = 28) was almost the same, i.e. ≈60% at 10 years. The median survival for all 251 patients registered was 8 years (historical controls 3.5 years). The role of the treatment schedule presented in the imatinib era is discussed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Adolescent
- Adult
- Antineoplastic Agents/administration & dosage
- Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
- Denmark
- Female
- Follow-Up Studies
- Hematopoietic Stem Cell Transplantation
- Humans
- Hydroxyurea/administration & dosage
- Interferons/administration & dosage
- Leukapheresis
- Leukemia; Myeloid; Philadelphia-Positive/mortality/*therapy
- Male
- Middle Aged
- Multicenter Studies
- Survival Analysis
- Sweden
- Transplantation; Autologous
- Transplantation; Homologous
- chronic myelogenous leukemia
- chemotherapy
- intensive
- interferon
- stem
- cell transplantation
- autologous and allogeneic
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Simonsson, Bengt
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Öberg, Gunnar
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Björeman, Mats
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Björkholm, Magnu ...
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Carneskog, Jan
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Karlsson, Karin
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show more...
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Gahrton, Gösta
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Grimfors, Gunnar
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Hast, Robert
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Karle, Hans
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Linder, Olle
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Ljungman, Per
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Nielsen, Johan L
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Nilsson, Jonas
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Löfvenberg, Eva
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Malm, Claes, 194 ...
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Olsson, Karin
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Olsson-Strömberg ...
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Paul, Christer
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Stenke, Leif
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Stentoft, Jesper
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Turesson, Ingema ...
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Udén, Ann-Marie
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Wahlin, Anders
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Vilén, Lars
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Weis-Bjerrum, Ol ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Acta Haematologi ...
- By the university
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Umeå University
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Lund University
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Uppsala University
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Karolinska Institutet
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Linköping University