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WFRF:(Mannino David M.)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008240naa a2200817 4500
001oai:DiVA.org:uu-512806
003SwePub
008230929s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-506649
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5128062 URI
0247 a https://doi.org/10.1186/s12931-023-02450-12 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5066492 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Knox-Brown, Benu Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.4 aut
2451 0a The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life :b results from the Burden of Obstructive Lung Disease (BOLD) study
264 1b BioMed Central (BMC),c 2023
338 a electronic2 rdacarrier
520 a BackgroundSpirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory symptoms, cardiometabolic diseases, and quality of life (QoL) is unknown.MethodsUsing data from the Burden of Obstructive Lung Disease study (N = 21,594), we defined spirometric SAO as the mean forced expiratory flow rate between 25 and 75% of the FVC (FEF25-75) less than the lower limit of normal (LLN) or the forced expiratory volume in 3 s to FVC ratio (FEV3/FVC) less than the LLN. We analysed data on respiratory symptoms, cardiometabolic diseases, and QoL collected using standardised questionnaires. We assessed the associations with spirometric SAO using multivariable regression models, and pooled site estimates using random effects meta-analysis. We conducted identical analyses for isolated spirometric SAO (i.e. with FEV1/FVC ≥ LLN).ResultsAlmost a fifth of the participants had spirometric SAO (19% for FEF25-75; 17% for FEV3/FVC). Using FEF25-75, spirometric SAO was associated with dyspnoea (OR = 2.16, 95% CI 1.77–2.70), chronic cough (OR = 2.56, 95% CI 2.08–3.15), chronic phlegm (OR = 2.29, 95% CI 1.77–4.05), wheeze (OR = 2.87, 95% CI 2.50–3.40) and cardiovascular disease (OR = 1.30, 95% CI 1.11–1.52), but not hypertension or diabetes. Spirometric SAO was associated with worse physical and mental QoL. These associations were similar for FEV3/FVC. Isolated spirometric SAO (10% for FEF25-75; 6% for FEV3/FVC), was also associated with respiratory symptoms and cardiovascular disease.ConclusionSpirometric SAO is associated with respiratory symptoms, cardiovascular disease, and QoL. Consideration should be given to the measurement of FEF25-75 and FEV3/FVC, in addition to traditional spirometry parameters.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Omvårdnad0 (SwePub)303052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nursing0 (SwePub)303052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a Spirometry
653 a Small airways obstruction
653 a Symptoms
653 a Cardiovascular disease
653 a Quality of life
7001 a Patel, Jayminiu Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.4 aut
7001 a Potts, Jamesu Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.4 aut
7001 a Ahmed, Ranau Epidemiol Lab Epilab, Khartoum, Sudan.4 aut
7001 a Aquart-Stewart, Altheau UWI, Dept Med, Mona, Jamaica.4 aut
7001 a Barbara, Cristinau Univ Lisbon, Fac Med, Inst Saude Ambiental, Lisbon, Portugal.;Ctr Hosp Univ Lisboa Norte, Serv Pneumol, Lisbon, Portugal.4 aut
7001 a Buist, A. Soniau Oregon Hlth & Sci Univ, Portland, OR USA.4 aut
7001 a Cherkaski, Hamid Haceneu Univ Badji Mokhtar Annaba, Fac Med Annaba, Dept Pneumol, Annaba, Algeria.4 aut
7001 a Denguezli, Meriamu Univ Monastir, Fac Med Dent Monastir, Ave Avicenne, Monastir, Tunisia.4 aut
7001 a Elbiaze, Mohammedu Mohammed Ben Abdellah Univ, Univ Hosp, Fac Med, Dept Resp Med, Fes, Morocco.,Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;CIRO, Dept Res & Educ, Horn, Netherlands.4 aut
7001 a Erhabor, Gregory E.u Obafemi Awolowo Univ, Ife, Osun, Nigeria.4 aut
7001 a Franssen, Frits M. E.u Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;CIRO, Dept Res & Educ, Horn, Netherlands.,Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.4 aut
7001 a Al Ghobain, Mohammedu King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, King Abdulaziz Med City, Minist Natl Guard Hlth Affairs, Riyadh, Saudi Arabia.4 aut
7001 a Gislason, Thorarinnu Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut
7001 a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning,Arbets- och miljömedicin,Klinisk fysiologi,Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden.4 aut0 (Swepub:uu)chrisjn
7001 a Kocabas, Aliu Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkiye.4 aut
7001 a Mannino, Davidu Univ Kentucky, Lexington, KY USA.;COPD Fdn, Miami, FL USA.4 aut
7001 a Marks, Guyu Woolcock Inst Med Res, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.;Univ New South Wales, Sydney, NSW, Australia.4 aut
7001 a Mortimer, Kevinu Univ Cambridge, Cambridge, England.;Liverpool Univ Hosp NHS Fdn Trust, Liverpool, England.4 aut
7001 a Nafees, Asaad Ahmedu Aga Khan Univ, Dept Community Hlth Sci, Karachi, Pakistan.4 aut
7001 a Obaseki, Danielu Obafemi Awolowo Univ, Ife, Osun, Nigeria.4 aut
7001 a Paraguas, Stefanni Nonna M.u Philippine Coll Chest Phys, Quezon City, Philippines.;Philippine Heart Ctr, Quezon City, Philippines.4 aut
7001 a Loh, Li Cheru RCSI & UCD Malaysia Campus, George Town, Malaysia.4 aut
7001 a Rashid, Abdulu RCSI & UCD Malaysia Campus, George Town, Malaysia.4 aut
7001 a Salvi, Sundeepu Pulmocare Res & Educ PURE Fdn, Pune, India.;Symbiosis Int Deemed Univ, Pune, India.,Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.4 aut
7001 a Seemungal, Terenceu Univ West Indies, Fac Med Sci, St Augustine, Trinidad Tobago.4 aut
7001 a Studnicka, Michaelu Paracelsus Med Univ Salzburg, Univ Clin Pneumol, Salzburg, Austria.4 aut
7001 a Tan, Wan C.u Univ British Columbia, Ctr Heart Lung Innovat, Vancouver, BC, Canada.4 aut
7001 a Wouters, Emiel F. M.u Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.4 aut
7001 a Abozid, Hazimu Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.4 aut
7001 a Mueller, Alexanderu Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.4 aut
7001 a Burney, Peteru Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.4 aut
7001 a Amaral, Andre F. S.u Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.4 aut
7102 a Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.b Epidemiol Lab Epilab, Khartoum, Sudan.4 org
7730 t Respiratory Researchd : BioMed Central (BMC)g 24:1q 24:1x 1465-9921x 1465-993X
8564 u https://doi.org/10.1186/s12931-023-02450-1y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1801277/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://uu.diva-portal.org/smash/get/diva2:1803753/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512806
8564 8u https://doi.org/10.1186/s12931-023-02450-1
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506649

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