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Advances in stem ce...
Advances in stem cell therapy for amyotrophic lateral sclerosis
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- Mazzini, Letizia (författare)
- Maggiore Carita Univ Hosp Novara, Dept Neurol, ALS Ctr, Novara, Italy
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- Ferrari, Daniela (författare)
- Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy
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- Andjus, Pavle R. (författare)
- Univ Belgrade, Fac Biol, Ctr Laser Microscopy, Belgrade, Serbia
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- Buzanska, Leonora (författare)
- Polish Acad Sci, Mossakowski Med Res Ctr, Stem Cell Bioengn Unit, Warsaw, Poland
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- Cantello, Roberto (författare)
- Maggiore Carita Univ Hosp Novara, Dept Neurol, ALS Ctr, Novara, Italy
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- De Marchi, Fabiola (författare)
- Maggiore Carita Univ Hosp Novara, Dept Neurol, ALS Ctr, Novara, Italy
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- Gelati, Maurizio (författare)
- IRCCS Casa Sollievo Sofferenza, Sci Direct, Foggia, Italy;Fdn Cellule Staminali, Cell Factory & Biobanca, Terni, Italy
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- Giniatullin, Rashid (författare)
- Univ Eastern Finland, AI Virtanen Inst Mol Sci, Neulaniementie 2, Kuopio, Finland
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- Glover, Joel C. (författare)
- Univ Oslo, Inst Basic Med Sci, Dept Mol Med, Oslo, Norway;Oslo Univ Hosp, Norwegian Ctr Stem Cell Res, Oslo, Norway
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- Grilli, Mariagrazia (författare)
- Univ Piemonte Orientale, Lab Neuroplast, Dept Pharmaceut Sci, Novara, Italy
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- Kozlova, Elena (författare)
- Uppsala universitet,Regenerativ neurobiologi
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- Maioli, Margherita (författare)
- Univ Sassari, CNR, Ist Ric Genet & Biomed, Dept Biomed Sci, Sassari, Italy;Univ Sassari, CNR, Ist Ric Genet & Biomed, Ctr Dev Biol & Reprogramming CEDEBIOR, Sassari, Italy
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- Mitrecic, Dinko (författare)
- Univ Zagreb, Sch Med, Croatian Inst Brain Res, Lab Stem Cells, Zagreb, Croatia
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- Pivoriunas, Augustas (författare)
- Ctr Innovat Med, State Res Inst, Dept Stem Cell Biol, Vilnius, Lithuania
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- Sanchez-Pernaute, Rosario (författare)
- Andalusian Hlth Minist, Andalusian Initiat Adv Therapies, Preclin Res, Seville, Spain
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- Sarnowska, Anna (författare)
- Polish Acad Sci, Mossakowski Med Res Ctr, Stem Cell Bioengn Unit, Warsaw, Poland
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- Vescovi, Angelo L. (författare)
- Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy;Fdn Cellule Staminali, Cell Factory & Biobanca, Terni, Italy
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(creator_code:org_t)
- 2018-07-31
- 2018
- Engelska.
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Ingår i: Expert Opinion on Biological Therapy. - : Informa UK Limited. - 1471-2598 .- 1744-7682. ; 18:8, s. 865-881
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Amyotrophic Lateral Sclerosis (ALS) is a progressive, incurable neurodegenerative disease that targets motoneurons. Cell-based therapies have generated widespread interest as a potential therapeutic approach but no conclusive results have yet been reported either from pre-clinical or clinical studies. Areas covered: This is an integrated review of pre-clinical and clinical studies focused on the development of cell-based therapies for ALS. We analyze the biology of stem cell treatments and results obtained from pre-clinical models of ALS and examine the methods and the results obtained to date from clinical trials. We discuss scientific, clinical, and ethical issues and propose some directions for future studies. Expert opinion: While data from individual studies are encouraging, stem-cell-based therapies do not yet represent a satisfactory, reliable clinical option. The field will critically benefit from the introduction of well-designed, randomized and reproducible, powered clinical trials. Comparative studies addressing key issues such as the nature, properties, and number of donor cells, the delivery mode and the selection of proper patient populations that may benefit the most from cell-based therapies are now of the essence. Multidisciplinary networks of experts should be established to empower effective translation of research into the clinic.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Amyotrophic lateral sclerosis
- stem cells
- transplantation
- clinical trials
- animal models
- cellular models
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- Av författaren/redakt...
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Mazzini, Letizia
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Ferrari, Daniela
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Andjus, Pavle R.
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Buzanska, Leonor ...
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Cantello, Robert ...
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De Marchi, Fabio ...
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visa fler...
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Gelati, Maurizio
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Giniatullin, Ras ...
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Glover, Joel C.
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Grilli, Mariagra ...
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Kozlova, Elena
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Maioli, Margheri ...
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Mitrecic, Dinko
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Pivoriunas, Augu ...
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Sanchez-Pernaute ...
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Sarnowska, Anna
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Vescovi, Angelo ...
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