Sökning: WFRF:(Mccarthy Kathryn) > Genome-wide associa...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07027naa a2201333 4500 | |
001 | oai:gup.ub.gu.se/264060 | |
003 | SwePub | |
008 | 240528s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2640602 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddx4292 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Beaumont, Robin N4 aut |
245 | 1 0 | a Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. |
264 | c 2018-01-03 | |
264 | 1 | b Oxford University Press (OUP),c 2018 |
520 | a Genome-wide association studies (GWAS) of birth weight have focused on fetal genetics, while relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86,577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P<5x10-8. In SEM analyses, at least 7 of the 10 associations were consistent with effects of the maternal genotype acting via the intrauterine environment, rather than via effects of shared alleles with the fetus. Variants, or correlated proxies, at many of the loci had been previously associated with adult traits, including fasting glucose (MTNR1B, GCK and TCF7L2) and sex hormone levels (CYP3A7), and one (EBF1) with gestational duration. The identified associations indicate genetic effects on maternal glucose, cytochrome P450 activity and gestational duration, and potentially on maternal blood pressure and immune function, are relevant for fetal growth. Further characterization of these associations in mechanistic and causal analyses will enhance understanding of the potentially modifiable maternal determinants of fetal growth, with the goal of reducing the morbidity and mortality associated with low and high birth weights. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
700 | 1 | a Warrington, Nicole M4 aut |
700 | 1 | a Cavadino, Alana4 aut |
700 | 1 | a Tyrrell, Jessica4 aut |
700 | 1 | a Nodzenski, Michael4 aut |
700 | 1 | a Horikoshi, Momoko4 aut |
700 | 1 | a Geller, Frank4 aut |
700 | 1 | a Myhre, Ronny4 aut |
700 | 1 | a Richmond, Rebecca C4 aut |
700 | 1 | a Paternoster, Lavinia4 aut |
700 | 1 | a Bradfield, Jonathan P4 aut |
700 | 1 | a Kreiner-Møller, Eskil4 aut |
700 | 1 | a Huikari, Ville4 aut |
700 | 1 | a Metrustry, Sarah4 aut |
700 | 1 | a Lunetta, Kathryn L4 aut |
700 | 1 | a Painter, Jodie N4 aut |
700 | 1 | a Hottenga, Jouke-Jan4 aut |
700 | 1 | a Allard, Catherine4 aut |
700 | 1 | a Barton, Sheila J4 aut |
700 | 1 | a Espinosa, Ana4 aut |
700 | 1 | a Marsh, Julie A4 aut |
700 | 1 | a Potter, Catherine4 aut |
700 | 1 | a Zhang, Ge4 aut |
700 | 1 | a Ang, Wei4 aut |
700 | 1 | a Berry, Diane J4 aut |
700 | 1 | a Bouchard, Luigi4 aut |
700 | 1 | a Das, Shikta4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Heikkinen, Jani4 aut |
700 | 1 | a Helgeland, Øyvind4 aut |
700 | 1 | a Hocher, Berthold4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Inskip, Hazel M4 aut |
700 | 1 | a Jones, Samuel E4 aut |
700 | 1 | a Kogevinas, Manolis4 aut |
700 | 1 | a Lind, Penelope A4 aut |
700 | 1 | a Marullo, Letizia4 aut |
700 | 1 | a Medland, Sarah E4 aut |
700 | 1 | a Murray, Anna4 aut |
700 | 1 | a Murray, Jeffrey C4 aut |
700 | 1 | a Njølstad, Pål R4 aut |
700 | 1 | a Nohr, Ellen A4 aut |
700 | 1 | a Reichetzeder, Christoph4 aut |
700 | 1 | a Ring, Susan M4 aut |
700 | 1 | a Ruth, Katherine S4 aut |
700 | 1 | a Santa-Marina, Loreto4 aut |
700 | 1 | a Scholtens, Denise M4 aut |
700 | 1 | a Sebert, Sylvain4 aut |
700 | 1 | a Sengpiel, Verena,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsenve |
700 | 1 | a Tuke, Marcus A4 aut |
700 | 1 | a Vaudel, Marc4 aut |
700 | 1 | a Weedon, Michael N4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a Wood, Andrew R4 aut |
700 | 1 | a Yaghootkar, Hanieh4 aut |
700 | 1 | a Muglia, Louis J4 aut |
700 | 1 | a Bartels, Meike4 aut |
700 | 1 | a Relton, Caroline L4 aut |
700 | 1 | a Pennell, Craig E4 aut |
700 | 1 | a Chatzi, Leda4 aut |
700 | 1 | a Estivill, Xavier4 aut |
700 | 1 | a Holloway, John W4 aut |
700 | 1 | a Boomsma, Dorret I4 aut |
700 | 1 | a Montgomery, Grant W4 aut |
700 | 1 | a Murabito, Joanne M4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a Power, Christine4 aut |
700 | 1 | a Järvelin, Marjo-Ritta4 aut |
700 | 1 | a Bisgaard, Hans4 aut |
700 | 1 | a Grant, Struan Fa4 aut |
700 | 1 | a Sørensen, Thorkild Ia4 aut |
700 | 1 | a Jaddoe, Vincent W4 aut |
700 | 1 | a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo |
700 | 1 | a Melbye, Mads4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Hattersley, Andrew T4 aut |
700 | 1 | a Hayes, M Geoffrey4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Felix, Janine F4 aut |
700 | 1 | a Hyppönen, Elina4 aut |
700 | 1 | a Lowe, William L4 aut |
700 | 1 | a Evans, David M4 aut |
700 | 1 | a Lawlor, Debbie A4 aut |
700 | 1 | a Feenstra, Bjarke4 aut |
700 | 1 | a Freathy, Rachel M4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
773 | 0 | t Human molecular geneticsd : Oxford University Press (OUP)g 27:4, s. 742-756q 27:4<742-756x 1460-2083x 1460-2083x 0964-6906 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/27/4/742/24325853/ddx429.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/264060 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddx429 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy