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Low-level exposure ...
Low-level exposure to polycyclic aromatic hydrocarbons is associated with reduced lung function among Swedish young adults
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- Alhamdow, Ayman (författare)
- Karolinska Institutet,Karolinska Institute
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- Zettergren, Anna (författare)
- Karolinska Institute
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- Kull, Inger (författare)
- Karolinska Institutet,Karolinska Institute
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- Hallberg, Jenny (författare)
- Karolinska Institutet,Karolinska Institute
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- Andersson, Niklas (författare)
- Karolinska Institutet,Karolinska Institute
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- Ekström, Sandra (författare)
- Karolinska Institutet,Karolinska Institute
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- Berglund, Marika (författare)
- Karolinska Institutet,Karolinska Institute
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- Wheelock, Craig E. (författare)
- Karolinska Institutet
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- Essig, Yona J. (författare)
- Skåne University Hospital
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- Krais, Annette M. (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Georgelis, Antonios (författare)
- Karolinska Institute
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- Lindh, Christian H. (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Melén, Erik (författare)
- Karolinska Institutet,Karolinska Institute
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- Bergström, Anna (författare)
- Karolinska Institute
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 197
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to adverse pulmonary effects. However, the impact of low-level environmental PAH exposure on lung function in early adulthood remains uncertain. Objectives: To evaluate the associations between urinary PAH metabolites and lung function parameters in young adults. Methods: Urinary metabolites of pyrene, phenanthrene, and fluorene were analysed in 1000 young adults from Sweden (age 22–25 years) using LC-MS/MS. Lung function and eosinophilic airway inflammation were measured by spirometry and exhaled nitric oxide fraction (FeNO), respectively. Linear regression analysis was used to evaluate associations between PAH metabolites and the outcomes. Results: Median urinary concentrations of 1-OH-pyrene, ∑OH-phenanthrene, and ∑OH-fluorene were 0.066, 0.36, 0.22 μg/L, respectively. We found inverse associations of ∑OH-phenanthrene and ∑OH-fluorene with FEV1 and FVC, as well as between 1-OH-pyrene and FEV1/FVC ratio (adjusted P < 0.05; all participants). An increase of 1% in ∑OH-fluorene was associated with a decrease of 73 mL in FEV1 and 59 mL in FVC. In addition, ∑OH-phenanthrene concentrations were, in a dose-response manner, inversely associated with FEV1 (B from −109 to −48 compared with the lowest quartile of ∑OH-phenanthrene; p trend 0.004) and FVC (B from −159 to −102 compared with lowest quartile; p-trend <0.001). Similar dose-response associations were also observed between ∑OH-fluorene and FEV1 and FVC, as well as between 1-OH-pyrene and FEV1/FVC (p-trend <0.05). There was no association between PAH exposure and FeNO, nor was there an interaction with smoking, sex, or asthma. Conclusion: Low-level PAH exposure was, in a dose-response manner, associated with reduced lung function in young adults. Our findings have public health implications due to i) the widespread occurrence of PAHs in the environment and ii) the clinical relevance of lung function in predicting all-cause and cardiovascular disease mortality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Air pollution
- Asthma
- Environmental exposure
- Polycyclic aromatic hydrocarbons
- Urinary metabolites
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Alhamdow, Ayman
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Zettergren, Anna
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Kull, Inger
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Hallberg, Jenny
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Andersson, Nikla ...
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Ekström, Sandra
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Berglund, Marika
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Wheelock, Craig ...
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Essig, Yona J.
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Krais, Annette M ...
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Georgelis, Anton ...
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Lindh, Christian ...
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Melén, Erik
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Bergström, Anna
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Environmental Re ...
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Lunds universitet
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Karolinska Institutet