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Circulating specifi...
Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo
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van Montfoort, Nadine (författare)
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- Mangsbo, Sara M (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
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Camps, Marcel G M (författare)
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van Maren, Wendy W C (författare)
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Verhaart, Ingrid E C (författare)
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Waisman, Ari (författare)
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Drijfhout, Jan Wouter (författare)
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Melief, Cornelis J M (författare)
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Verbeek, J Sjef (författare)
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Ossendorp, Ferry (författare)
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(creator_code:org_t)
- 2012-04-09
- 2012
- Engelska.
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 42:3, s. 598-606
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Increasing evidence suggests that antibodies can have stimulatory effects on T-cell immunity. However, the contribution of circulating antigen-specific antibodies on MHC class I cross-priming in vivo has not been conclusively established. Here, we defined the role of circulating antibodies in cross-presentation of antigen to CD8+ T cells. Mice with hapten-specific circulating antibodies, but naϊve for the T-cell antigen, were infused with haptenated antigen and CD8+ T-cell induction was measured. Mice with circulating hapten-specific antibodies showed significantly enhanced cross-presentation of the injected antigen compared with mice that lacked these antibodies. The enhanced cross-presentation in mice with circulating antigen-specific antibodies was associated with improved antigen capture by APCs. Importantly, CD11c+ APCs were responsible for the enhanced and sustained cross-presentation, although CD11c− APCs had initially captured a significant amount of the injected antigen. Thus, in vivo formation of antigen-antibody immune complexes improves MHC class I cross-presentation, and CD8+ T-cell activation, demonstrating that humoral immunity can aid the initiation of systemic cellular immunity. These findings have important implications for the understanding of the action of therapeutic antibodies against tumor-associated antigens intensively used in the clinic nowadays.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- art (ämneskategori)
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van Montfoort, N ...
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Mangsbo, Sara M
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Camps, Marcel G ...
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van Maren, Wendy ...
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Verhaart, Ingrid ...
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Waisman, Ari
-
visa fler...
-
Drijfhout, Jan W ...
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Melief, Cornelis ...
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Verbeek, J Sjef
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Ossendorp, Ferry
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visa färre...
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Uppsala universitet