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Radiological follow...
Radiological follow-up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
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- Aarnivala, Henri (författare)
- Oulu Univ Hosp, Finland; Univ Oulu, Finland
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- Giertz, Mia (författare)
- Uppsala Univ Hosp, Sweden; Uppsala Univ, Sweden
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- Michelsen, Sascha Wilk (författare)
- Univ Hosp Rigshospitalet, Denmark
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- Bjorklund, Caroline (författare)
- Umea Univ Hosp, Sweden
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- Englund, Annika (författare)
- Uppsala Univ Hosp, Sweden; Uppsala Univ, Sweden
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- Gronroos, Marika (författare)
- Turku Univ Hosp, Finland
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- Hjalgrim, Lisa Lyngsie (författare)
- Univ Hosp Rigshospitalet, Denmark
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- Huttunen, Pasi (författare)
- Univ Helsinki, Finland
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- Niinimaki, Tuukka (författare)
- Univ Oulu, Finland; Oulu Univ Hosp, Finland
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- Penno, Eva (författare)
- Uppsala Univ Hosp, Sweden
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- Pokka, Tytti (författare)
- Oulu Univ Hosp, Finland
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- Poyhonen, Tuuli (författare)
- Kuopio Univ Hosp, Finland
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- Raittinen, Paeivi (författare)
- Tampere Univ, Finland
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- Ranta, Susanna (författare)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Svahn, Johan E. (författare)
- Lund Univ, Sweden
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- Törnudd, Lisa (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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- Harila, Arja (författare)
- Uppsala Univ, Sweden
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- Niinimaki, Riitta (författare)
- Oulu Univ Hosp, Finland; Univ Oulu, Finland
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Osteonecrosis (ON) is a common complication of glucocorticoid-based Hodgkin lymphoma (HL) treatment, but the natural evolution and prognosis of ON lesions remain poorly understood. We describe the radiological evolution of ON lesions identified in a Nordic population-based cohort of paediatric HL patients. Magnetic resonance images of suspected ON lesions were centrally reviewed to confirm ON diagnosis and grade the ON lesions according to the Niinim & auml;ki classification. The study included 202 ON lesions in 46 patients, of which 77 were joint lesions. Follow-up images were available for 146/202 lesions, with a mean follow-up time of 28 months. During follow-up, 71% of the lesions remained stable, 26% improved or resolved, and 3% progressed. A higher ON grade at diagnosis was associated with a lower likelihood of spontaneous resolution. The likelihood for resolution of ON decreased by 50% for each year of added patient age, when adjusted for sex, ON location, and symptoms. Hip ON showed less spontaneous improvement compared with other joints, and the risk for surgery was 13-fold in hip ON. Grades 3-4 joint ON has the potential to either progress or resolve, warranting follow-up in patients with severe symptoms. Research on secondary prevention should be directed at grade 3-4 joint ON. Osteonecrosis (ON) is a recognised complication of glucocorticoid-based treatment for Hodgkin lymphoma (HL). In a Nordic cohort of 489 paediatric HL patients, a magnetic resonance imaging follow-up study using the Niinim & auml;ki radiological classification system was carried out. Forty-six patients had been diagnosed with ON. A total of 202 ON were identified, of which 77 were joint lesions. Follow-up images were available for 146/202 lesions, with a mean follow-up time of 28 months. During follow-up, 3% of the lesions progressed to joint collapse, whilst 26% improved or resolved. A higher ON grade at diagnosis was associated with a lower likelihood for spontaneous resolution, as was higher patient age. Hip ON showed less spontaneous improvement compared with other joints, and the risk for surgery was 13-fold in hip ON.image
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- avascular necrosis; Hodgkin lymphoma; osteonecrosis; paediatric
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Aarnivala, Henri
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Giertz, Mia
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Michelsen, Sasch ...
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Bjorklund, Carol ...
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Englund, Annika
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Gronroos, Marika
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Hjalgrim, Lisa L ...
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Huttunen, Pasi
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Niinimaki, Tuukk ...
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Penno, Eva
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Pokka, Tytti
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Poyhonen, Tuuli
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Raittinen, Paeiv ...
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Ranta, Susanna
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Svahn, Johan E.
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Törnudd, Lisa
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Harila, Arja
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Niinimaki, Riitt ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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British Journal ...
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Linköpings universitet