Radiological follow-up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma

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Radiological follow-up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma

Aarnivala, Henri (författare): Oulu Univ Hosp, Finland; Univ Oulu, Finland

Giertz, Mia (författare): Uppsala Univ Hosp, Sweden; Uppsala Univ, Sweden

Michelsen, Sascha Wilk (författare): Univ Hosp Rigshospitalet, Denmark

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Bjorklund, Caroline (författare): Umea Univ Hosp, Sweden

Englund, Annika (författare): Uppsala Univ Hosp, Sweden; Uppsala Univ, Sweden

Gronroos, Marika (författare): Turku Univ Hosp, Finland

Hjalgrim, Lisa Lyngsie (författare): Univ Hosp Rigshospitalet, Denmark

Huttunen, Pasi (författare): Univ Helsinki, Finland

Niinimaki, Tuukka (författare): Univ Oulu, Finland; Oulu Univ Hosp, Finland

Penno, Eva (författare): Uppsala Univ Hosp, Sweden

Pokka, Tytti (författare): Oulu Univ Hosp, Finland

Poyhonen, Tuuli (författare): Kuopio Univ Hosp, Finland

Raittinen, Paeivi (författare): Tampere Univ, Finland

Ranta, Susanna (författare): Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden

Svahn, Johan E. (författare): Lund Univ, Sweden

Törnudd, Lisa (författare): Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus

Harila, Arja (författare): Uppsala Univ, Sweden

Niinimaki, Riitta (författare): Oulu Univ Hosp, Finland; Univ Oulu, Finland

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2024
2024
Engelska.
Ingår i: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141.

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Osteonecrosis (ON) is a common complication of glucocorticoid-based Hodgkin lymphoma (HL) treatment, but the natural evolution and prognosis of ON lesions remain poorly understood. We describe the radiological evolution of ON lesions identified in a Nordic population-based cohort of paediatric HL patients. Magnetic resonance images of suspected ON lesions were centrally reviewed to confirm ON diagnosis and grade the ON lesions according to the Niinim & auml;ki classification. The study included 202 ON lesions in 46 patients, of which 77 were joint lesions. Follow-up images were available for 146/202 lesions, with a mean follow-up time of 28 months. During follow-up, 71% of the lesions remained stable, 26% improved or resolved, and 3% progressed. A higher ON grade at diagnosis was associated with a lower likelihood of spontaneous resolution. The likelihood for resolution of ON decreased by 50% for each year of added patient age, when adjusted for sex, ON location, and symptoms. Hip ON showed less spontaneous improvement compared with other joints, and the risk for surgery was 13-fold in hip ON. Grades 3-4 joint ON has the potential to either progress or resolve, warranting follow-up in patients with severe symptoms. Research on secondary prevention should be directed at grade 3-4 joint ON. Osteonecrosis (ON) is a recognised complication of glucocorticoid-based treatment for Hodgkin lymphoma (HL). In a Nordic cohort of 489 paediatric HL patients, a magnetic resonance imaging follow-up study using the Niinim & auml;ki radiological classification system was carried out. Forty-six patients had been diagnosed with ON. A total of 202 ON were identified, of which 77 were joint lesions. Follow-up images were available for 146/202 lesions, with a mean follow-up time of 28 months. During follow-up, 3% of the lesions progressed to joint collapse, whilst 26% improved or resolved. A higher ON grade at diagnosis was associated with a lower likelihood for spontaneous resolution, as was higher patient age. Hip ON showed less spontaneous improvement compared with other joints, and the risk for surgery was 13-fold in hip ON.image

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

avascular necrosis; Hodgkin lymphoma; osteonecrosis; paediatric

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Hematologi

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Av lärosätet: Linköpings universitet

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