Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers

Tajeddinn, W. (author)

Fereshtehnejad, S. M. (author)

Ahmed, M. S. (author)

Yoshitake, T. (author)

Kehr, J. (author)

Shahnaz, T. (author)

Milovanovic, M. (author)

Behbahani, H. (author)

Höglund, Kina, 1976 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Winblad, B. (author)

Cedazo-Minguez, A. (author)

Jelic, V. (author)

Jaremo, P. (author)

Aarsland, D. (author)

(creator_code:org_t)

IOS Press, 2016
2016
English.
In: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 53:2, s. 621-630

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.3...; show less...

Abstract Subject headings

Introduction: Serotonin (5-HT) is involved in the pathology of Alzheimer's disease (AD). Objective: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (A beta(42)), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Methods: 15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC-ECD). Results: Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normalization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/A beta(42) ratio (p = 0.001), compared to those with high 5-HT levels. Conclusion: AD patients have reduced platelet 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden.

By the author/editor: Tajeddinn, W.; Fereshtehnejad, ...; Ahmed, M. S.; Yoshitake, T.; Kehr, J.; Shahnaz, T.; show more...; Milovanovic, M.; Behbahani, H.; Höglund, Kina, 1 ...; Winblad, B.; Cedazo-Minguez, ...; Jelic, V.; Jaremo, P.; Aarsland, D.; show less...

About the subject

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