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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05505naa a2201141 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:152011311 | |
| 003 | SwePub | |
| 008 | 240701s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1520113112 URI |
| 024 | 7 | a https://doi.org/10.1136/bmjgh-2022-0094952 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Smith, ER4 aut |
| 245 | 1 0 | a Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis |
| 264 | c 2023-01-16 | |
| 264 | 1 | b BMJ,c 2023 |
| 520 | a Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol. | |
| 700 | 1 | a Oakley, E4 aut |
| 700 | 1 | a Grandner, GW4 aut |
| 700 | 1 | a Ferguson, K4 aut |
| 700 | 1 | a Farooq, F4 aut |
| 700 | 1 | a Afshar, Y4 aut |
| 700 | 1 | a Ahlberg, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Ahmadzia, H4 aut |
| 700 | 1 | a Akelo, V4 aut |
| 700 | 1 | a Aldrovandi, G4 aut |
| 700 | 1 | a Barr, BAT4 aut |
| 700 | 1 | a Bevilacqua, E4 aut |
| 700 | 1 | a Brandt, JS4 aut |
| 700 | 1 | a Broutet, N4 aut |
| 700 | 1 | a Buhigas, IF4 aut |
| 700 | 1 | a Carrillo, J4 aut |
| 700 | 1 | a Clifton, R4 aut |
| 700 | 1 | a Conry, J4 aut |
| 700 | 1 | a Cosmi, E4 aut |
| 700 | 1 | a Crispi, F4 aut |
| 700 | 1 | a Crovetto, F4 aut |
| 700 | 1 | a Delgado-Lopez, C4 aut |
| 700 | 1 | a Divakar, H4 aut |
| 700 | 1 | a Driscoll, AJ4 aut |
| 700 | 1 | a Favre, G4 aut |
| 700 | 1 | a Flaherman, VJ4 aut |
| 700 | 1 | a Gale, C4 aut |
| 700 | 1 | a Gil, MM4 aut |
| 700 | 1 | a Gottlieb, SL4 aut |
| 700 | 1 | a Gratacos, E4 aut |
| 700 | 1 | a Hernandez, O4 aut |
| 700 | 1 | a Jones, S4 aut |
| 700 | 1 | a Kalafat, E4 aut |
| 700 | 1 | a Khagayi, S4 aut |
| 700 | 1 | a Knight, M4 aut |
| 700 | 1 | a Kotloff, K4 aut |
| 700 | 1 | a Lanzone, A4 aut |
| 700 | 1 | a Le Doare, K4 aut |
| 700 | 1 | a Lees, C4 aut |
| 700 | 1 | a Litman, E4 aut |
| 700 | 1 | a Lokken, EM4 aut |
| 700 | 1 | a Longo, VL4 aut |
| 700 | 1 | a Madhi, SA4 aut |
| 700 | 1 | a Magee, LA4 aut |
| 700 | 1 | a Martinez-Portilla, RJ4 aut |
| 700 | 1 | a McClure, EM4 aut |
| 700 | 1 | a Metz, TD4 aut |
| 700 | 1 | a Miller, ES4 aut |
| 700 | 1 | a Money, D4 aut |
| 700 | 1 | a Moungmaithong, S4 aut |
| 700 | 1 | a Mullins, E4 aut |
| 700 | 1 | a Nachega, JB4 aut |
| 700 | 1 | a Nunes, MC4 aut |
| 700 | 1 | a Onyango, D4 aut |
| 700 | 1 | a Panchaud, A4 aut |
| 700 | 1 | a Poon, LC4 aut |
| 700 | 1 | a Raiten, D4 aut |
| 700 | 1 | a Regan, L4 aut |
| 700 | 1 | a Rukundo, G4 aut |
| 700 | 1 | a Sahota, D4 aut |
| 700 | 1 | a Sakowicz, A4 aut |
| 700 | 1 | a Sanin-Blair, J4 aut |
| 700 | 1 | a Soderling, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Stephansson, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Temmerman, M4 aut |
| 700 | 1 | a Thorson, A4 aut |
| 700 | 1 | a Tolosa, JE4 aut |
| 700 | 1 | a Townson, J4 aut |
| 700 | 1 | a Valencia-Prado, M4 aut |
| 700 | 1 | a Visentin, S4 aut |
| 700 | 1 | a von Dadelszen, P4 aut |
| 700 | 1 | a Waldorf, KA4 aut |
| 700 | 1 | a Whitehead, C4 aut |
| 700 | 1 | a Yassa, M4 aut |
| 700 | 1 | a Tielsch, JM4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t BMJ global healthd : BMJg 8:1q 8:1x 2059-7908 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152011311 |
| 856 | 4 8 | u https://doi.org/10.1136/bmjgh-2022-009495 |
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- Smith, ER
- Oakley, E
- Grandner, GW
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- Ahlberg, M
- Ahmadzia, H
- Akelo, V
- Aldrovandi, G
- Barr, BAT
- Bevilacqua, E
- Brandt, JS
- Broutet, N
- Buhigas, IF
- Carrillo, J
- Clifton, R
- Conry, J
- Cosmi, E
- Crispi, F
- Crovetto, F
- Delgado-Lopez, C
- Divakar, H
- Driscoll, AJ
- Favre, G
- Flaherman, VJ
- Gale, C
- Gil, MM
- Gottlieb, SL
- Gratacos, E
- Hernandez, O
- Jones, S
- Kalafat, E
- Khagayi, S
- Knight, M
- Kotloff, K
- Lanzone, A
- Le Doare, K
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- Litman, E
- Lokken, EM
- Longo, VL
- Madhi, SA
- Magee, LA
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- McClure, EM
- Metz, TD
- Miller, ES
- Money, D
- Moungmaithong, S
- Mullins, E
- Nachega, JB
- Nunes, MC
- Onyango, D
- Panchaud, A
- Poon, LC
- Raiten, D
- Regan, L
- Rukundo, G
- Sahota, D
- Sakowicz, A
- Sanin-Blair, J
- Soderling, J
- Stephansson, O
- Temmerman, M
- Thorson, A
- Tolosa, JE
- Townson, J
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- Visentin, S
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