Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

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Fältnamn	Indikatorer	Metadata
000		07084naa a2201213 4500
001		oai:lup.lub.lu.se:63c9393a-89ed-4178-8180-7aabcf107793
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/23488682 URI
024	7	a https://doi.org/10.1001/jama.2012.202 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Bolton, Kelly L.4 aut
245	1 0	a Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer
264	1	b American Medical Association (AMA),c 2012
520		a Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. Objective To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns. Design, Setting, and Participants A pooled analysis of 26 observational studies on the survival of women with ovarian cancer, which included data from 1213 EOC cases with pathogenic germline mutations in BRCA1 (n=909) or BRCA2 (n=304) and from 2666 noncarriers recruited and followed up at variable times between 1987 and 2010 (the median year of diagnosis was 1998). Main Outcome Measure Five-year overall mortality. Results The 5-year overall survival was 36% (95% CI, 34%-38%) for noncarriers, 44% (95% CI, 40%-48%) for BRCA1 carriers, and 52% (95% CI, 46%-58%) for BRCA2 carriers. After adjusting for study and year of diagnosis, BRCA1 and BRCA2 mutation carriers showed a more favorable survival than noncarriers (for BRCA1: hazard ratio [HR], 0.78; 95% CI, 0.68-0.89; P<.001; and for BRCA2: HR, 0.61; 95% CI, 0.50-0.76; P<.001). These survival differences remained after additional adjustment for stage, grade, histology, and age at diagnosis (for BRCA1: HR, 0.73; 95% CI, 0.64-0.84; P<.001; and for BRCA2: HR, 0.49; 95% CI, 0.39-0.61; P<.001). The BRCA1 HR estimate was significantly different from the HR estimated in the adjusted model (P for heterogeneity=.003). Conclusion Among patients with invasive EOC, having a germline mutation in BRCA1 or BRCA2 was associated with improved 5-year overall survival. BRCA2 carriers had the best prognosis. JAMA. 2012;307(4):382-390
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Goh, Cindy4 aut
700	1	a Sadetzki, Siegal4 aut
700	1	a Ramus, Susan J.4 aut
700	1	a Karlan, Beth Y.4 aut
700	1	a Lambrechts, Diether4 aut
700	1	a Despierre, Evelyn4 aut
700	1	a Barrowdale, Daniel4 aut
700	1	a McGuffog, Lesley4 aut
700	1	a Healey, Sue4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Sinilnikova, Olga4 aut
700	1	a Benitez, Javier4 aut
700	1	a Garcia, Maria J.4 aut
700	1	a Neuhausen, Susan4 aut
700	1	a Gail, Mitchell H.4 aut
700	1	a Hartge, Patricia4 aut
700	1	a Peock, Susan4 aut
700	1	a Frost, Debra4 aut
700	1	a Evans, Gareth4 aut
700	1	a Eeles, Rosalind4 aut
700	1	a Godwin, Andrew K.4 aut
700	1	a Daly, Mary B.4 aut
700	1	a Kwong, Ava4 aut
700	1	a Ma, Edmond S. K.4 aut
700	1	a Lazaro, Conxi4 aut
700	1	a Blanco, Ignacio4 aut
700	1	a Montagna, Marco4 aut
700	1	a D'Andrea, Emma4 aut
700	1	a Nicoletto, Maria Ornella4 aut
700	1	a Johnatty, Sharon E.4 aut
700	1	a Krueger, Susanne4 aut
700	1	a Jensen, Allan4 aut
700	1	a Hogdall, Estrid4 aut
700	1	a Goode, Ellen L.4 aut
700	1	a Fridley, Brooke L.4 aut
700	1	a Loud, Jennifer T.4 aut
700	1	a Greene, Mark H.4 aut
700	1	a Mai, Phuong L.4 aut
700	1	a Chetrit, Angela4 aut
700	1	a Lubin, Flora4 aut
700	1	a Hirsh-Yechezkel, Galit4 aut
700	1	a Glendon, Gord4 aut
700	1	a Andrulis, Irene L.4 aut
700	1	a Toland, Amanda E.4 aut
700	1	a Senter, Leigha4 aut
700	1	a Gore, Martin E.4 aut
700	1	a Gourley, Charlie4 aut
700	1	a Michie, Caroline O.4 aut
700	1	a Song, Honglin4 aut
700	1	a Tyrer, Jonathan4 aut
700	1	a Whittemore, Alice S.4 aut
700	1	a McGuire, Valerie4 aut
700	1	a Sieh, Weiva4 aut
700	1	a Kristoffersson, Ulfu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-ukr
700	1	a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol
700	1	a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
700	1	a Levine, Douglas A.4 aut
700	1	a Steele, Linda4 aut
700	1	a Beattie, Mary S.4 aut
700	1	a Chan, Salina4 aut
700	1	a Nussbaum, Robert L.4 aut
700	1	a Moysich, Kirsten B.4 aut
700	1	a Gross, Jenny4 aut
700	1	a Cass, Ilana4 aut
700	1	a Walsh, Christine4 aut
700	1	a Li, Andrew J.4 aut
700	1	a Leuchter, Ronald4 aut
700	1	a Gordon, Ora4 aut
700	1	a Garcia-Closas, Montserrat4 aut
700	1	a Gayther, Simon A.4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Antoniou, Antonis C.4 aut
700	1	a Pharoah, Paul D. P.4 aut
710	2	a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
773	0	t JAMA: The Journal of the American Medical Associationd : American Medical Association (AMA)g 307:4, s. 382-390q 307:4<382-390x 1538-3598
773	0	t JAMAd : American Medical Association (AMA)g 307:4, s. 382-390q 307:4<382-390x 0098-7484
856	4	u http://dx.doi.org/10.1001/jama.2012.20y FULLTEXT
856	4	u https://jamanetwork.com/journals/jama/articlepdf/1104901/joc15157_382_390.pdf
856	4 8	u https://lup.lub.lu.se/record/2348868
856	4 8	u https://doi.org/10.1001/jama.2012.20

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Av författaren/redakt...: Bolton, Kelly L.; Chenevix-Trench, ...; Goh, Cindy; Sadetzki, Siegal; Ramus, Susan J.; Karlan, Beth Y.; visa fler...; Lambrechts, Diet ...; Despierre, Evely ...; Barrowdale, Dani ...; McGuffog, Lesley; Healey, Sue; Easton, Douglas ...; Sinilnikova, Olg ...; Benitez, Javier; Garcia, Maria J.; Neuhausen, Susan; Gail, Mitchell H ...; Hartge, Patricia; Peock, Susan; Frost, Debra; Evans, Gareth; Eeles, Rosalind; Godwin, Andrew K ...; Daly, Mary B.; Kwong, Ava; Ma, Edmond S. K.; Lazaro, Conxi; Blanco, Ignacio; Montagna, Marco; D'Andrea, Emma; Nicoletto, Maria ...; Johnatty, Sharon ...; Krueger, Susanne; Jensen, Allan; Hogdall, Estrid; Goode, Ellen L.; Fridley, Brooke ...; Loud, Jennifer T ...; Greene, Mark H.; Mai, Phuong L.; Chetrit, Angela; Lubin, Flora; Hirsh-Yechezkel, ...; Glendon, Gord; Andrulis, Irene ...; Toland, Amanda E ...; Senter, Leigha; Gore, Martin E.; Gourley, Charlie; Michie, Caroline ...; Song, Honglin; Tyrer, Jonathan; Whittemore, Alic ...; McGuire, Valerie; Sieh, Weiva; Kristoffersson, ...; Olsson, Håkan; Borg, Åke; Levine, Douglas ...; Steele, Linda; Beattie, Mary S.; Chan, Salina; Nussbaum, Robert ...; Moysich, Kirsten ...; Gross, Jenny; Cass, Ilana; Walsh, Christine; Li, Andrew J.; Leuchter, Ronald; Gordon, Ora; Garcia-Closas, M ...; Gayther, Simon A ...; Chanock, Stephen ...; Antoniou, Antoni ...; Pharoah, Paul D. ...; visa färre...

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