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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004630naa a2200721 4500
001oai:lup.lub.lu.se:c0f2b2b7-2f15-4dbf-9928-2b4bd278c00c
003SwePub
008160401s2007 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:116232722
0247 a https://lup.lub.lu.se/record/9690272 URI
0247 a https://doi.org/10.1086/5228642 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1162327222 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Villa, Luisa L.4 aut
2451 0a Prophylactic efficacy of a quadrivalent human papillomavirus (HPV) vaccine in women with virological evidence of HPV infection
264 1b Oxford University Press (OUP),c 2007
520 a Background. A quadrivalent (types 6, 11, 16, and 18) human papillomavirus (HPV) L1 virus-like-particle (VLP) vaccine has been shown to be 95%-100% effective in preventing cervical and genital disease related to HPV-6,-11,-16, and-18 in 16-26-year-old women naive for HPV vaccine types. Because most women in the general population are sexually active, some will have already been infected with >= 1 HPV vaccine types at the time vaccination is offered. Here, we assessed whether such infected women are protected against disease caused by the remaining HPV vaccine types. Methods. Two randomized, placebo-controlled trials of the quadrivalent (types 6, 11, 16, and 18) HPV vaccine enrolled 17,622 women without consideration of baseline HPV status. Among women infected with 1-3 HPV vaccine types at enrollment, efficacy against genital disease related to the HPV vaccine type or types for which subjects were naive was assessed. Results. Vaccination was 100% effective (95% confidence interval [CI], 79%-100%) in preventing incident cervical intraepithelial neoplasia 2 or 3 or cervical adenocarcinoma in situ caused by the HPV type or types for which the women were negative at enrollment. Efficacy for preventing vulvar or vaginal HPV-related lesions was 94% (95% CI, 81%-99%). Conclusions. Among women positive for 1-3 HPV vaccine types before vaccination, the quadrivalent HPV vaccine protected against neoplasia caused by the remaining types. These results support vaccination of the general population without prescreening.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Perez, Gonzalo4 aut
7001 a Kjaer, Susanne Krueger4 aut
7001 a Paavonen, Jorma4 aut
7001 a Lehtinen, Matti4 aut
7001 a Munoz, Nubia4 aut
7001 a Sigurdsson, Kristjan4 aut
7001 a Hernandez-Avila, Mauricio4 aut
7001 a Iversen, Ole Eric4 aut
7001 a Thoresen, Steinar4 aut
7001 a Garcia, Patricia J.4 aut
7001 a Majewski, Slawomir4 aut
7001 a Tay, Eng Hseon4 aut
7001 a Bosch, F. Xavier4 aut
7001 a Dillner, Joakimu Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-jdi
7001 a Olsson, Sven-Ericu Karolinska Institutet4 aut
7001 a Ault, Kevin A.4 aut
7001 a Brown, Darron R.4 aut
7001 a Ferris, Daron G.4 aut
7001 a Koutsky, Laura A.4 aut
7001 a Kurman, Robert J.4 aut
7001 a Myers, Evan R.4 aut
7001 a Barr, Eliav4 aut
7001 a Boslego, John4 aut
7001 a Bryan, Janine4 aut
7001 a Esser, Mark T.4 aut
7001 a Hesley, Teresa M.4 aut
7001 a Nelson, Micki4 aut
7001 a Railkar, Radha4 aut
7001 a James, Margaret4 aut
7001 a Sattler, Carlos4 aut
7001 a Taddeo, Frank J.4 aut
7001 a Thornton, Annemarie R.4 aut
7001 a Vuocolo, Scott C.4 aut
7102 a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Infectious Diseasesd : Oxford University Press (OUP)g 196:10, s. 1438-1446q 196:10<1438-1446x 1537-6613x 0022-1899
8564 u http://dx.doi.org/10.1086/522864x freey FULLTEXT
8564 u https://academic.oup.com/jid/article-pdf/196/10/1438/18049618/196-10-1438.pdf
8564 8u https://lup.lub.lu.se/record/969027
8564 8u https://doi.org/10.1086/522864
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:116232722

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