Sökning: WFRF:(Nelson Christopher)
> (2005-2009) >
Evidence for the in...
Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species
-
- Ren, Hongzu (författare)
- NHEERL, ORD, US EPA, Research Triangle Park, NC, United States; NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC, United States
-
- Vallanat, Beena (författare)
- NHEERL, ORD, US EPA, Research Triangle Park, NC, United States; NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC, United States
-
- Nelson, David M. (författare)
- Discovery Toxicology, Bristol-Myers Squibb Company, Princeton, NJ, United States
-
visa fler...
-
- Yeung, Leo W. Y., 1981- (författare)
- Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki, Japan; Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, Hong Kong
-
- Guruge, Keerthi S. (författare)
- Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki, Japan
-
- Lam, Paul K. S. (författare)
- Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, Hong Kong
-
- Lehman-McKeeman, Lois D. (författare)
- Discovery Toxicology, Bristol-Myers Squibb Company, Princeton, NJ, United States
-
- Corton, J. Christopher (författare)
- NHEERL, ORD, US EPA, Research Triangle Park, NC, United States; NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC, United States
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2009
- 2009
- Engelska.
-
Ingår i: Reproductive Toxicology. - : Elsevier. - 0890-6238 .- 1873-1708. ; 27:3-4, s. 266-277
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Humans and ecological species have been found to have detectable body burdens of a number of perfluorinated alkyl acids (PFAA) including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). In mouse and rat liver these compounds elicit transcriptional and phenotypic effects similar to peroxisome proliferator chemicals (PPC) that work through the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα). Recent studies indicate that along with PPARα other nuclear receptors are required for transcriptional changes in the mouse liver after PFOA exposure including the constitutive activated receptor (CAR) and pregnane X receptor (PXR) that regulate xenobiotic metabolizing enzymes (XME). To determine the potential role of CAR/PXR in mediating effects of PFAAs in rat liver, we performed a meta-analysis of transcript profiles from published studies in which rats were exposed to PFOA or PFOS. We compared the profiles to those produced by exposure to prototypical activators of CAR, (phenobarbital (PB)), PXR (pregnenolone 16 alpha-carbonitrile (PCN)), or PPARα (WY-14,643 (WY)). As expected, PFOA and PFOS elicited transcript profile signatures that included many known PPARα target genes. Numerous XME genes were also altered by PFOA and PFOS but not WY. These genes exhibited expression changes shared with PB or PCN. Reexamination of the transcript profiles from the livers of chicken or fish exposed to PFAAs indicated that PPARα, CAR, and PXR orthologs were not activated. Our results indicate that PFAAs under these experimental conditions activate PPARα, CAR, and PXR in rats but not chicken and fish. Lastly, we discuss evidence that human populations with greater CAR expression have lower body burdens of PFAAs.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Liver cancer; Perfluorinated alkyl acids; Perfluorooctane sulfonate; Perfluorooctanoic acid; Peroxisome proliferators
- Enviromental Science
- Miljövetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas