Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia

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Fältnamn	Indikatorer	Metadata
000		04487naa a2200481 4500
001		oai:DiVA.org:umu-50743
003		SwePub
008		111220s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:73f7b744-99b8-43f1-af57-94ac1ca84d82
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-507432 URI
024	7	a https://doi.org/10.1111/j.1471-4159.2011.07292.x2 DOI
024	7	a https://lup.lub.lu.se/record/19732772 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Nevalainen, Ninau Umeå universitet,Histologi med cellbiologi4 aut0 (Swepub:umu)nine0001
245	1 0	a Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia
264		c 2011-05-25
264	1	b Wiley,c 2011
338		a print2 rdacarrier
520		a L-DOPA is the most commonly used treatment for symptomatic control in patients with Parkinson's disease. Unfortunately, most patients develop severe side-effects, such as dyskinesia, upon chronic l-DOPA treatment. The patophysiology of dyskinesia is unclear; however, involvement of serotonergic nerve fibers in converting l-DOPA to dopamine has been suggested. Therefore, potassium-evoked dopamine release was studied after local application of l-DOPA in the striata of normal, dopamine- and dopamine/serotonin-lesioned l-DOPA naïve, and dopamine-denervated chronically l-DOPA-treated dyskinetic rats using in vivo chronoamperometry. The results revealed that local l-DOPA administration into normal and intact hemisphere of dopamine-lesioned l-DOPA naïve animals significantly increased the potassium-evoked dopamine release. l-DOPA application also increased the dopamine peak amplitude in the dopamine-depleted l-DOPA naïve striatum, although these dopamine levels were several-folds lower than in the normal striatum, whereas no increased dopamine release was found in the dopamine/serotonin-denervated striatum. In dyskinetic animals, local l-DOPA application did not affect the dopamine release, resulting in significantly attenuated dopamine levels compared with those measured in l-DOPA naïve dopamine-denervated striatum. To conclude, l-DOPA is most likely converted to dopamine in serotonergic nerve fibers in the dopamine-depleted striatum, but the dopamine release is several-fold lower than in normal striatum. Furthermore, l-DOPA loading does not increase the dopamine release in dyskinetic animals as found in l-DOPA naïve animals, despite similar density of serotonergic innervation. Thus, the dopamine overflow produced from the serotonergic nerve fibers appears not to be the major cause of dyskinetic behavior.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a 5-HT
653		a chronoamperometry
653		a L-DOPA-induced dyskinesia
653		a SERT
700	1	a Af Bjerkén, Sarau Umeå universitet,Histologi med cellbiologi4 aut0 (Swepub:umu)saaafn99
700	1	a Lundblad, Martinu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-mlu
700	1	a Gerhardt, Greg Au Anatomy, Neurobiology, and Neurology, University of Kentucky Med Center, Lexington, KY, USA4 aut
700	1	a Strömberg, Ingridu Umeå universitet,Histologi med cellbiologi4 aut0 (Swepub:umu)inst0001
710	2	a Umeå universitetb Histologi med cellbiologi4 org
773	0	t Journal of Neurochemistryd : Wileyg 118:1, s. 12-23q 118:1<12-23x 0022-3042x 1471-4159
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2011.07292.x
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/21534956?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1111/j.1471-4159.2011.07292.xy FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50743
856	4 8	u https://doi.org/10.1111/j.1471-4159.2011.07292.x
856	4 8	u https://lup.lub.lu.se/record/1973277

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Av författaren/redakt...: Nevalainen, Nina; Af Bjerkén, Sara; Lundblad, Martin; Gerhardt, Greg A; Strömberg, Ingri ...

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