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Body mass index and molecular subtypes of colorectal cancer

Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Newton, Christina C. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Song, Mingyang (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
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Papadimitriou, Nikos (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Phipps, Amanda I. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
Aglago, Elom K. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, UK
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia
Cao, Yin (författare)
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA; Alvin J. Siteman Cancer Center, St Louis, MO, USA
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
Chen, Xuechen (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
Cheng, Iona (författare)
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Dimou, Niki (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Drew, David (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Farris, Alton B. (författare)
Department of Pathology, Emory University, Atlanta, GA, USA
French, Amy J. (författare)
Division of Laboratory Genetics, Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA
Gallinger, Steven (författare)
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Georgeson, Peter (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia
Giannakis, Marios (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA
Giles, Graham G. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
Gruber, Stephen B. (författare)
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA
Huang, Wen-Yi (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia
Laskar, Ruhina S. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI, USA
Limburg, Paul (författare)
Mayo Clinic, Rochester, MN, USA
Lin, Yi (författare)
Mayo Clinic, Rochester, MN, USA
Mandic, Marko (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Nowak, Johnathan A. (författare)
Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Obon-Santacana, Mereia (författare)
Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ogino, Shuji (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA
Schoen, Robert E. (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Southey, Melissa C. (författare)
Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
Stadler, Zsofia K. (författare)
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Steinfelder, Robert S. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
Sun, Wei (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
Thibodeau, Stephen N. (författare)
Mayo Clinic, Rochester, MN, USA
Toland, Amanda E. (författare)
Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Trinh, Quang M. (författare)
Ontario Institute for Cancer Research, Toronto, ON, Canada
Tsilidis, Kostas K. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, UK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Ugai, Tomotaka (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA; Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
van Guelpen, Bethany (författare)
Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
Wang, Xiaoliang (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
Woods, Michael O. (författare)
Memorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada
Zaidi, Syed H. (författare)
Ontario Institute for Cancer Research, Toronto, ON, Canada
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA
Campbell, Peter T. (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
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Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France Department of Epidemiology, Harvard TH. Chan School of Public Health, Harvard University, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA (creator_code:org_t)
2022-11-29
2023
Engelska.
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 115:2, s. 165-173
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease.Methods: We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables.Results: Higher BMI was associated with increased CRC risk (OR per 5 kg/m(2) = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control).Conclusions: In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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