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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003681naa a2200529 4500
001oai:gup.ub.gu.se/306888
003SwePub
008240528s2021 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3068882 URI
0247 a https://doi.org/10.5507/bp.2020.0352 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Brat, K.4 aut
2451 0a Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index
264 1b Palacky University Olomouc,c 2021
520 a Objectives. The BODE (BMI, Obstruction - FEV1, Dyspnoea - mMRC, Exercise - 6-MWT) and the ADO (Age, Dyspnoea - mMRC, Obstruction - FEV1) indices are widely used prognosis assessment tools for long-term mortality prediction in COPD patients but subject to limitations for use in daily clinical practice. The aim of this research was to construct a prognostic instrument that prevents these limitations and which would serve as a complementary prognostic tool for clinical use in these patients. Methods and Participants. The data of 699 COPD subjects were extracted from the Czech Multicentre Research Database (CMRD) of COPD patients (the derivation cohort) and analysed to identify factors associated with the long-term risk of mortality. These were entered into the ROC analysis and reclassification analysis. Those with the strongest discriminative power were used to construct the new index (CADOT). The new index was validated on 187 patients of the CIROCO+ cohort (Netherlands; the validation cohort). Results. The CADOT was constructed by adding two newly identified prognosis-determining factors, chronic heart failure (CHF) and TLCO, to the ADO index. In a head-to-head comparison, the CADOT index showed highest c-statistic values compared to the BODE and ADO indices (0.701 vs 0.677 vs 0.644, respectively). The prognostic power was more definitive when applied to the Dutch validation (CIROCO+) cohort (0.842 vs 0.799 vs 0.825, respectively). Conclusions. The CADOT index has comparable prognostic power to the BODE and ADO indices.The CADOT is complementary/an alternative to the BODE (if 6-MWT is not feasible) and ADO (with less dependence on the age factor) indices.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a COPD
653 a prognostic index
653 a pulmonary function
653 a mortality
653 a acute exacerbations
653 a bode index
653 a pulmonary
653 a Engineering
653 a Research & Experimental Medicine
7001 a Svoboda, M.4 aut
7001 a Hejduk, K.4 aut
7001 a Plutinsky, M.4 aut
7001 a Zatloukal, J.4 aut
7001 a Volakova, E.4 aut
7001 a Popelkova, P.4 aut
7001 a Novotna, B.4 aut
7001 a Engova, D.4 aut
7001 a Franssen, F. M. E.4 aut
7001 a Vanfleteren, Lowie E G Wu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xvanlo
7001 a Spruit, M. A.4 aut
7001 a Koblizek, V.4 aut
7102 a Göteborgs universitetb Institutionen för medicin4 org
7730 t Biomedical Papers-Olomoucd : Palacky University Olomoucg 165:2, s. 139-145q 165:2<139-145x 1213-8118x 1804-7521
8564 u http://biomed.papers.upol.cz/doi/10.5507/bp.2020.035.pdf
8564 8u https://gup.ub.gu.se/publication/306888
8564 8u https://doi.org/10.5507/bp.2020.035

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