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Human antibodies to...
Human antibodies to herpes simplex virus type 1 glycoprotein C are neutralizing and target the heparan sulfate-binding domain
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- Adamiak, Beata (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Trybala, Edward, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Mardberg, K. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Johansson, M. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Liljeqvist, Jan-Åke, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Olofsson, Sigvard, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Grabowska, A. (author)
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Bienkowska-Szewczyk, K. (author)
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Szewczyk, B. (author)
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Virology. - : Elsevier BV. - 0042-6822. ; 400:2, s. 197-206
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https://doi.org/10.1...
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Abstract
Subject headings
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- Human antibodies specific for glycoprotein C (gC1) of herpes simplex virus type 1 (HSV-1) neutralized the virus infectivity and efficiently inhibited attachment of HSV-1 to human HaCaT keratinocytes and to murine mutant L cells expressing either heparan sulfate or chondroitin sulfate at the cell surface. Similar activities were observed with anti-gC1 monoclonal antibody B1C1. In addition to HaCaT and L cells, B1C1 antibody neutralized HSV-1 infectivity in simian GMK AH1 cells mildly pre-treated with heparinase III. Human anti-gC1 antibodies efficiently competed with the binding of gC1 to B1C1 antibody whose epitope overlaps a part of the attachment domain of gC1. Human anti-gC1 and B1C1 antibodies extended survival time of mice experimentally infected with HSV-1. We conclude that in HaCaT cells and in cell systems showing restricted expression of glycosaminoglycans, human and some monoclonal anti-gC1 antibodies can target the cell-binding domain of this protein and neutralize viral infectivity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Animals
- Antibodies
- Neutralizing/*immunology
- Antibodies
- Viral/*immunology
- Binding Sites
- Cell Line
- Cercopithecus aethiops
- Disease Models
- Animal
- Epitopes/immunology
- Heparitin Sulfate/metabolism
- Herpes Simplex/immunology
- Herpesvirus 1
- Human/*immunology
- Humans
- Keratinocytes/virology
- Mice
- Neutralization Tests
- Survival Analysis
- Viral Envelope Proteins/*immunology
- Virus Attachment
Publication and Content Type
- ref (subject category)
- art (subject category)
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Virology
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- By the author/editor
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Adamiak, Beata
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Trybala, Edward, ...
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Mardberg, K.
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Johansson, M.
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Liljeqvist, Jan- ...
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Olofsson, Sigvar ...
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Grabowska, A.
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Bienkowska-Szewc ...
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Szewczyk, B.
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Bergström, Tomas ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Virology
- By the university
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University of Gothenburg