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Identification of c...
Identification of c-Fos immunoreactive brainstem neurons activated during fictive mastication in the rabbit
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- Athanassiadis, Tuija, 1971- (author)
- Umeå universitet,Fysiologi
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- Olsson, Kurt A (author)
- Umeå universitet,Fysiologi
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Kolta, A (author)
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- Westberg, Karl-Gunnar (author)
- Umeå universitet,Fysiologi
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(creator_code:org_t)
- 2005-05-11
- 2005
- English.
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In: Experimental Brain Research. - : Springer Science and Business Media LLC. - 0014-4819 .- 1432-1106. ; 165:4, s. 478-489
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In the present study we used the expression of the c-Fos-like protein as a "functional marker" to map populations of brainstem neurons involved in the generation of mastication. Experiments were conducted on urethane-anesthetized and paralyzed rabbits. In five animals (experimental group), rhythmical bouts of fictive masticatory-like motoneuron activity (cumulative duration 60-130 min) were induced by electrical stimulation of the left cortical "masticatory area" and recorded from the right digastric motoneuron pool. A control group of five animals (non-masticatory) were treated in the same way as the experimental animals with regard to surgical procedures, anesthesia, paralysis, and survival time. To detect the c-Fos-like protein, the animals were perfused, and the brainstems were cryosectioned and processed immunocytochemically. In the experimental group, the number of c-Fos-like immunoreactive neurons increased significantly in several brainstem areas. In rostral and lateral areas, increments occurred bilaterally in the borderzones surrounding the trigeminal motor nucleus (Regio h); the rostrodorsomedial half of the trigeminal main sensory nucleus; subnucleus oralis-gamma of the spinal trigeminal tract; nuclei reticularis parvocellularis pars alpha and nucleus reticularis pontis caudalis (RPc) pars alpha. Further caudally-enhanced labeling occurred bilaterally in nucleus reticularis parvocellularis and nucleus reticularis gigantocellularis (Rgc) including its pars-alpha. Our results provide a detailed anatomical record of neuronal populations that are correlated with the generation of the masticatory motor behavior.
Keyword
- Anesthesia
- Animals
- Brain Stem/*metabolism
- Data Interpretation; Statistical
- Efferent Pathways/cytology/physiology
- Electric Stimulation
- Immunohistochemistry
- Male
- Mastication/*physiology
- Masticatory Muscles/innervation/physiology
- Microelectrodes
- Motor Cortex/physiology
- Motor Neurons/physiology
- Neurons/*metabolism
- Paralysis/physiopathology
- Proto-Oncogene Proteins c-fos/*metabolism
- Rabbits
Publication and Content Type
- ref (subject category)
- art (subject category)
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