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3D high spatial resolution visualisation and quantification of interconnectivity in polymer films

Fager, Cecilia, 1990 (författare)
Chalmers University of Technology, Sweden,Chalmers tekniska högskola
Eriksson Barman, Sandra, 1985 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden
Röding, Magnus (författare)
RISE,Jordbruk och livsmedel,RISE Research Institutes of Sweden
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Olsson, Anna, 1985 (författare)
AstraZeneca, Sweden,AstraZeneca AB
Loren, Niklas (författare)
RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,RISE Research Institutes of Sweden,Chalmers tekniska högskola
von Corswant, C. (författare)
AstraZeneca, Sweden,AstraZeneca AB
Bolin, David, 1983 (författare)
King Abdullah University of Science and Technology, Saudi Arabia,King Abdullah University of Science and Technology (KAUST)
Rootzen, Holger, 1945 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden
Olsson, Eva, 1960 (författare)
Chalmers University of Technology, Sweden,Chalmers tekniska högskola
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 (creator_code:org_t)
Elsevier B.V. 2020
2020
Engelska.
Ingår i: International Journal of Pharmaceutics. - : Elsevier B.V.. - 0378-5173 .- 1873-3476. ; 587
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • A porous network acts as transport paths for drugs through films for controlled drug release. The interconnectivity of the network strongly influences the transport properties. It is therefore important to quantify the interconnectivity and correlate it to transport properties for control and design of new films. This work presents a novel method for 3D visualisation and analysis of interconnectivity. High spatial resolution 3D data on porous polymer films for controlled drug release has been acquired using a focused ion beam (FIB) combined with a scanning electron microscope (SEM). The data analysis method enables visualisation of pore paths starting at a chosen inlet pore, dividing them into groups by length, enabling a more detailed quantification and visualisation. The method also enables identification of central features of the porous network by quantification of channels where pore paths coincide. The method was applied to FIB-SEM data of three leached ethyl cellulose (EC)/hydroxypropyl cellulose (HPC) films with different weight percentages. The results from the analysis were consistent with the experimentally measured release properties of the films. The interconnectivity and porosity increase with increasing amount of HPC. The bottleneck effect was strong in the leached film with lowest porosity. 

Ämnesord

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Kemiteknik -- Polymerteknologi (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Chemical Engineering -- Polymer Technologies (hsv//eng)
NATURVETENSKAP  -- Fysik -- Annan fysik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences -- Other Physics Topics (hsv//eng)
NATURVETENSKAP  -- Matematik (hsv//swe)
NATURAL SCIENCES  -- Mathematics (hsv//eng)

Nyckelord

3D
Bottlenecks
Focused ion beam
Geodesic channels
Geodesic paths
Interconnectivity
Polymer
Porosity
Scanning electron microscopy
Visualisation
ethyl cellulose
hydroxypropylcellulose
porous polymer
Article
controlled drug release
data visualization
electron beam
focused ion beam scanning electron microscopy tomography
image segmentation
priority journal
quantitative analysis
three-dimensional imaging
Interconnectivity
Visualisation
3D
Porosity
Polymer
Focused ion
beam
Scanning electron microscopy
Geodesic paths
Geodesic channels
Bottlenecks
pore structure
microstructure
tomography
cellulose
permeability
connectivity
tortuosity
diffusion
paper
Pharmacology & Pharmacy

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