Sökning: WFRF:(Padhan Narendra) > VEGFR2 pY949 signal...
Fältnamn | Indikatorer | Metadata |
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000 | 06669naa a2200625 4500 | |
001 | oai:DiVA.org:uu-288617 | |
003 | SwePub | |
008 | 160428s2016 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:c2e400ca-9245-4b48-ab14-9182ab341a61 | |
009 | oai:prod.swepub.kib.ki.se:133216076 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2886172 URI |
024 | 7 | a https://doi.org/10.1038/ncomms110172 DOI |
024 | 7 | a https://lup.lub.lu.se/record/c2e400ca-9245-4b48-ab14-9182ab341a612 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1332160762 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Li, Xiujuanu Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)xilix168 |
245 | 1 0 | a VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread |
264 | c 2016-03-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a electronic2 rdacarrier | |
520 | a The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished Y949 signalling in the mouse mutant Vegfr2(Y949F/Y949F) leads to VEGFA-resistant endothelial adherens junctions and a block in molecular extravasation. Vessels in Vegfr2(Y949F/Y949F) mice remain sensitive to inflammatory cytokines, and vascular morphology, blood pressure and flow parameters are normal. Tumour-bearing Vegfr2(Y949F/Y949F) mice display reduced vascular leakage and oedema, improved response to chemotherapy and, importantly, reduced metastatic spread. The inflammatory infiltration in the tumour micro-environment is unaffected. Blocking VEGFA-induced disassembly of endothelial junctions, thereby suppressing tumour oedema and metastatic spread, may be preferable to full vascular suppression in the treatment of certain cancer forms. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Padhan, Narendrau Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi,Uppsala Univ, Sci Life Lab, Rudbeck Lab, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden.4 aut0 (Swepub:uu)narpa396 |
700 | 1 | a Sjöström, Elisabet O.u Uppsala University,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Sci Life Lab, Rudbeck Lab, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden.4 aut0 (Swepub:uu)elioh874 |
700 | 1 | a Roche, Francis P.u Uppsala University,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)fraro724 |
700 | 1 | a Testini, Chiarau Uppsala University,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)chite685 |
700 | 1 | a Honkura, Naokiu Uppsala University,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)naoho135 |
700 | 1 | a Sainz-Jaspeado, Miguelu Uppsala University,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)migsa268 |
700 | 1 | a Gordon, Emmau Uppsala University,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)emmgo163 |
700 | 1 | a Bentley, Katieu Uppsala University,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, 330 Brookline Ave, Boston, MA 02215 USA.4 aut0 (Swepub:uu)katbe363 |
700 | 1 | a Philippides, Andrewu Univ Sussex, Ctr Computat Neurosci & Robot, Chichester 1 CI 104, Brighton BN1 9RH, E Sussex, England.,University of Sussex4 aut |
700 | 1 | a Tolmachev, Vladimiru Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)vladtolm |
700 | 1 | a Dejana, Elisabettau Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,IFOM IEO Campus, Via Adamello 16, I-20139 Milan, Italy.4 aut0 (Swepub:uu)elide443 |
700 | 1 | a Stan, Radu V.u Dartmouth Coll, Dept Pathol, Geisel Sch Med Dartmouth, Lebanon, NH 03756 USA.4 aut |
700 | 1 | a Vestweber, Dietmaru Max Planck Inst Mol Biomed, Dept Vasc Cell Biol, Rontgenstr 20, D-48149 Munster, Germany.4 aut |
700 | 1 | a Ballmer-Hofer, Kurtu Paul Scherrer Inst, Biomol Res, Mol Cell Biol, CH-5232 Villigen, Switzerland.4 aut |
700 | 1 | a Betsholtz, Christeru Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Med Biochem & Biophys, Div Vasc Biol, S-17177 Stockholm, Sweden.4 aut0 (Swepub:uu)chbet517 |
700 | 1 | a Pietras, Kristianu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Experimentell onkologi,Forskargrupper vid Lunds universitet,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Experimental oncology,Lund University Research Groups,Lund Univ, Medicon Village, Translat Canc Res, Bldg 404-A3, S-22381 Lund, Sweden.4 aut0 (Swepub:lu)med-kpi |
700 | 1 | a Jansson, Leifu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)leifjans |
700 | 1 | a Claesson-Welsh, Lenau Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)lcl04207 |
710 | 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 7q 7x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/ncomms11017y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:927096/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/ncomms11017.pdf |
856 | 4 | u http://dx.doi.org/10.1038/ncomms11017x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-288617 |
856 | 4 8 | u https://doi.org/10.1038/ncomms11017 |
856 | 4 8 | u https://lup.lub.lu.se/record/c2e400ca-9245-4b48-ab14-9182ab341a61 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133216076 |
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