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Sökning: WFRF:(Pedersen Bente Klarlund) > Epigenome- and Tran...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005269naa a2200601 4500
001oai:lup.lub.lu.se:61621856-6bb7-49ed-8457-f9f9a2913e20
003SwePub
008191107s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/61621856-6bb7-49ed-8457-f9f9a2913e202 URI
0247 a https://doi.org/10.1080/07435800.2019.16691602 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Broholm, Christau Copenhagen University Hospital4 aut
2451 0a Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men
264 c 2019-09-30
264 1b Informa UK Limited,c 2020
300 a 14 s.
520 a Background: Being born with low birth weight (LBW) is a risk factor for muscle insulin resistance and type 2 diabetes (T2D), which may be mediated by epigenetic mechanisms programmed by the intrauterine environment. Epigenetic mechanisms exert their prime effects in developing cells. We hypothesized that muscle insulin resistance in LBW subjects may be due to early differential epigenomic and transcriptomic alterations in their immature muscle progenitor cells. Results: Muscle progenitor cells were obtained from 23 healthy young adult men born at term with LBW, and 15 BMI-matched normal birth weight (NBW) controls. The cells were subsequently cultured and differentiated into myotubes. DNA and RNA were harvested before and after differentiation for genome-wide DNA methylation and RNA expression measurements. After correcting for multiple comparisons (q ≤ 0.05), 56 CpG sites were found to be significantly, differentially methylated in myoblasts from LBW compared with NBW men, of which the top five gene-annotated CpG sites (SKI, ARMCX3, NR5A2, NEUROG, ESRRG) previously have been associated to regulation of cholesterol, fatty acid and glucose metabolism and muscle development or hypertrophy. LBW men displayed markedly decreased myotube gene expression levels of the AMPK-repressing tyrosine kinase gene FYN and the histone deacetylase gene HDAC7. Silencing of FYN and HDAC7 was associated with impaired myotube formation, which for HDAC7 reduced muscle glucose uptake. Conclusions: The data provides evidence of impaired muscle development predisposing LBW individuals to T2D is linked to and potentially caused by distinct DNA methylation and transcriptional changes including down regulation of HDAC7 and FYN in their immature myoblast stem cells.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a epigenetics
653 a FAM8A1
653 a FYN
653 a HDAC7
653 a Low birth weight
653 a myogenesis
653 a skeletal muscle
7001 a Ribel-Madsen, Rasmusu Danish Diabetes Academy,Copenhagen University Hospital4 aut
7001 a Hjort, Lineu University of Copenhagen,Copenhagen University Hospital4 aut0 (Swepub:lu)li1517hj
7001 a Olsson, Anders Henriku Copenhagen University Hospital4 aut0 (Swepub:lu)med-a_o
7001 a Ahlers, Juliane Maria Dorotheeu Copenhagen University Hospital4 aut
7001 a Hansen, Ninna Schiøleru Copenhagen University Hospital,University of Copenhagen4 aut
7001 a Schrölkamp, Marenu Copenhagen University Hospital4 aut
7001 a Gillberg, Linnu Copenhagen University Hospital4 aut0 (Swepub:lu)med-lge
7001 a Perfilyev, Alexanderu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)med-apy
7001 a Volkov, Petru Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups4 aut0 (Swepub:lu)med-pvo
7001 a Ling, Charlotteu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-cl0
7001 a Jørgensen, Sine W.u Steno Diabetes Center Copenhagen4 aut
7001 a Mortensen, Brynjulfu Steno Diabetes Center Copenhagen4 aut
7001 a Hingst, Janneu University of Copenhagen4 aut
7001 a Wojtaszewski, Jørgenu University of Copenhagen4 aut
7001 a Scheele, Camillau Copenhagen University Hospital,University of Copenhagen4 aut
7001 a Brøns, Charlotteu Copenhagen University Hospital4 aut
7001 a Pedersen, Bente Klarlundu University of Copenhagen4 aut
7001 a Vaag, Allanu Copenhagen University Hospital,AstraZeneca, Sweden,University of Copenhagen4 aut0 (Swepub:lu)med-ava
7102 a Copenhagen University Hospitalb Danish Diabetes Academy4 org
7730 t Endocrine Researchd : Informa UK Limitedg 45:1, s. 58-71q 45:1<58-71x 0743-5800x 1532-4206
8564 u http://dx.doi.org/10.1080/07435800.2019.1669160y FULLTEXT
8564 8u https://lup.lub.lu.se/record/61621856-6bb7-49ed-8457-f9f9a2913e20
8564 8u https://doi.org/10.1080/07435800.2019.1669160

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