Sökning: WFRF:(Perez Boza J) > Inflammatory bowel ...
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000 | 06410naa a2200613 4500 | |
001 | oai:lup.lub.lu.se:a977488c-ff06-4895-ba50-645b6d252815 | |
003 | SwePub | |
008 | 240226s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/a977488c-ff06-4895-ba50-645b6d2528152 URI |
024 | 7 | a https://doi.org/10.1111/nan.129622 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Espinosa-Oliva, Ana M.u University Hospital Virgen del Rocío,University of Seville4 aut |
245 | 1 0 | a Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain |
264 | 1 | c 2024 |
520 | a Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods: We have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS-based rat model of gut inflammation in terms of α-syn pathology. Results: Our data support the existence of pathogenic α-syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS-based rat model of gut inflammation to demonstrate (i) the appearance of P-α-syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α-syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD. Conclusion: These results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut-brain axis in initiating α-syn aggregation and transport to the substantia nigra, resulting in neurodegeneration. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a alpha-synuclein | |
653 | a inflammatory bowel disease | |
653 | a neurodegeneration | |
653 | a neuroinflammation | |
653 | a Parkinson's disease | |
700 | 1 | a Ruiz, Rocíou University of Seville,University Hospital Virgen del Rocío4 aut |
700 | 1 | a Soto, Manuel Sarmientou University of Oxford,University of Seville,University Hospital Virgen del Rocío4 aut |
700 | 1 | a Boza-Serrano, Antoniou Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Seville,University Hospital Virgen del Rocío4 aut0 (Swepub:lu)med-ab_ |
700 | 1 | a Rodriguez-Perez, Ana I.u CIBER Enfermedades Neurodegenerativas (CIBERNED),CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)4 aut |
700 | 1 | a Roca-Ceballos, María A.u University Hospital Virgen del Rocío,University of Seville4 aut |
700 | 1 | a García-Revilla, Juanu University of Seville,University Hospital Virgen del Rocío4 aut |
700 | 1 | a Santiago, Martiu University of Seville,University Hospital Virgen del Rocío4 aut |
700 | 1 | a Serres, Sébastienu University of Oxford,University of Nottingham4 aut |
700 | 1 | a Economopoulus, Vasilikiu University of Oxford4 aut |
700 | 1 | a Carvajal, Ana E.u University of Seville4 aut |
700 | 1 | a Vázquez-Carretero, María D.u University of Seville4 aut |
700 | 1 | a García-Miranda, Pablou University of Seville4 aut |
700 | 1 | a Klementieva, Oxanau Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Medicinsk mikrospektroskopi,Forskargrupper vid Lunds universitet,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,LU profilområde: Proaktivt åldrande,Other operations, LTH,Faculty of Engineering, LTH,Medical Microspectroscopy,Lund University Research Groups,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,LU Profile Area: Proactive Ageing4 aut0 (Swepub:lu)med-oka |
700 | 1 | a Oliva-Martín, María J.u University of Seville,University Hospital Virgen del Rocío4 aut |
700 | 1 | a Deierborg, Tomasu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)expb-tol |
700 | 1 | a Rivas, Eloyu University Hospital Virgen del Rocío4 aut |
700 | 1 | a Sibson, Nicola R.u University of Oxford4 aut |
700 | 1 | a Labandeira-García, José L.u CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),CIBER Enfermedades Neurodegenerativas (CIBERNED)4 aut |
700 | 1 | a Machado, Albertou University Hospital Virgen del Rocío,University of Seville4 aut |
700 | 1 | a Peral, María J.u University of Seville4 aut |
700 | 1 | a Herrera, Antonio J.u University Hospital Virgen del Rocío,University of Seville4 aut |
700 | 1 | a Venero, José L.u University Hospital Virgen del Rocío,University of Seville4 aut |
700 | 1 | a de Pablos, Rocío M.u University Hospital Virgen del Rocío,University of Seville4 aut |
710 | 2 | a University Hospital Virgen del Rocíob University of Seville4 org |
773 | 0 | t Neuropathology and Applied Neurobiologyg 50:1q 50:1x 0305-1846 |
856 | 4 | u http://dx.doi.org/10.1111/nan.12962x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/a977488c-ff06-4895-ba50-645b6d252815 |
856 | 4 8 | u https://doi.org/10.1111/nan.12962 |
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