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WFRF:(Perez Boza J)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006410naa a2200613 4500
001oai:lup.lub.lu.se:a977488c-ff06-4895-ba50-645b6d252815
003SwePub
008240226s2024 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/a977488c-ff06-4895-ba50-645b6d2528152 URI
0247 a https://doi.org/10.1111/nan.129622 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Espinosa-Oliva, Ana M.u University Hospital Virgen del Rocío,University of Seville4 aut
2451 0a Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain
264 1c 2024
520 a Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods: We have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS-based rat model of gut inflammation in terms of α-syn pathology. Results: Our data support the existence of pathogenic α-syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS-based rat model of gut inflammation to demonstrate (i) the appearance of P-α-syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α-syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD. Conclusion: These results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut-brain axis in initiating α-syn aggregation and transport to the substantia nigra, resulting in neurodegeneration.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a alpha-synuclein
653 a inflammatory bowel disease
653 a neurodegeneration
653 a neuroinflammation
653 a Parkinson's disease
7001 a Ruiz, Rocíou University of Seville,University Hospital Virgen del Rocío4 aut
7001 a Soto, Manuel Sarmientou University of Oxford,University of Seville,University Hospital Virgen del Rocío4 aut
7001 a Boza-Serrano, Antoniou Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Seville,University Hospital Virgen del Rocío4 aut0 (Swepub:lu)med-ab_
7001 a Rodriguez-Perez, Ana I.u CIBER Enfermedades Neurodegenerativas (CIBERNED),CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)4 aut
7001 a Roca-Ceballos, María A.u University Hospital Virgen del Rocío,University of Seville4 aut
7001 a García-Revilla, Juanu University of Seville,University Hospital Virgen del Rocío4 aut
7001 a Santiago, Martiu University of Seville,University Hospital Virgen del Rocío4 aut
7001 a Serres, Sébastienu University of Oxford,University of Nottingham4 aut
7001 a Economopoulus, Vasilikiu University of Oxford4 aut
7001 a Carvajal, Ana E.u University of Seville4 aut
7001 a Vázquez-Carretero, María D.u University of Seville4 aut
7001 a García-Miranda, Pablou University of Seville4 aut
7001 a Klementieva, Oxanau Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Medicinsk mikrospektroskopi,Forskargrupper vid Lunds universitet,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,LU profilområde: Proaktivt åldrande,Other operations, LTH,Faculty of Engineering, LTH,Medical Microspectroscopy,Lund University Research Groups,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,LU Profile Area: Proactive Ageing4 aut0 (Swepub:lu)med-oka
7001 a Oliva-Martín, María J.u University of Seville,University Hospital Virgen del Rocío4 aut
7001 a Deierborg, Tomasu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)expb-tol
7001 a Rivas, Eloyu University Hospital Virgen del Rocío4 aut
7001 a Sibson, Nicola R.u University of Oxford4 aut
7001 a Labandeira-García, José L.u CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),CIBER Enfermedades Neurodegenerativas (CIBERNED)4 aut
7001 a Machado, Albertou University Hospital Virgen del Rocío,University of Seville4 aut
7001 a Peral, María J.u University of Seville4 aut
7001 a Herrera, Antonio J.u University Hospital Virgen del Rocío,University of Seville4 aut
7001 a Venero, José L.u University Hospital Virgen del Rocío,University of Seville4 aut
7001 a de Pablos, Rocío M.u University Hospital Virgen del Rocío,University of Seville4 aut
7102 a University Hospital Virgen del Rocíob University of Seville4 org
7730 t Neuropathology and Applied Neurobiologyg 50:1q 50:1x 0305-1846
8564 u http://dx.doi.org/10.1111/nan.12962x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/a977488c-ff06-4895-ba50-645b6d252815
8564 8u https://doi.org/10.1111/nan.12962

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