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Sökning: WFRF:(Pettersson Olga Vinnere) > Genome dynamics of ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003690naa a2200397 4500
001oai:DiVA.org:uu-108379
003SwePub
008090917s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1083792 URI
0247 a https://doi.org/10.1186/1471-2164-11-1522 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Berglund, Eva C.u Uppsala universitet,Molekylär evolution4 aut
2451 0a Genome dynamics of Bartonella grahamii in micro-populations of woodland rodents
264 c 2010-03-04
264 1b Springer Science and Business Media LLC,c 2010
338 a print2 rdacarrier
520 a Background: Rodents represent a high-risk reservoir for the emergence of new human pathogens. The recent completion of the 2.3 Mb genome of Bartonella grahamii, one of the most prevalent blood-borne bacteria in wild rodents, revealed a higher abundance of genes for host-cell interaction systems than in the genomes of closely related human pathogens. The sequence variability within the global B. grahamii population was recently investigated by multi locus sequence typing, but no study on the variability of putative host-cell interaction systems has been performed. Results: To study the population dynamics of B. grahamii, we analyzed the genomic diversity on a whole-genome scale of 27 B. grahamii strains isolated from four different species of wild rodents in three geographic locations separated by less than 30 km. Even using highly variable spacer regions, only 3 sequence types were identified. This low sequence diversity contrasted with a high variability in genome content. Microarray comparative genome hybridizations identified genes for outer surface proteins, including a repeated region containing the fha gene for filamentous hemaggluttinin and a plasmid that encodes a type IV secretion system, as the most variable. The estimated generation times in liquid culture medium for a subset of strains ranged from 5 to 22 hours, but did not correlate with sequence type or presence/absence patterns of the fha gene or the plasmid. Conclusion: Our study has revealed a geographic microstructure of B. grahamii in wild rodents. Despite near-identity in nucleotide sequence, major differences were observed in gene presence/absence patterns that did not segregate with host species. This suggests that genetically similar strains can infect a range of different hosts.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a Biology
653 a Biologi
7001 a Ehrenborg, Christianu Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)chriehre
7001 a Vinnere Pettersson, Olgau Uppsala universitet,Molekylär evolution4 aut
7001 a Granberg, Fredriku Uppsala universitet,Molekylär evolution4 aut
7001 a Näslund, Kristinau Uppsala universitet,Molekylär evolution4 aut
7001 a Holmberg, Martinu Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)martholm
7001 a Andersson, Siv G. E.u Uppsala universitet,Molekylär evolution4 aut0 (Swepub:uu)san07069
7102 a Uppsala universitetb Molekylär evolution4 org
7730 t BMC Genomicsd : Springer Science and Business Media LLCg 11, s. 152-q 11<152-x 1471-2164
8564 u https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/1471-2164-11-152
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108379
8564 8u https://doi.org/10.1186/1471-2164-11-152

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