The genomic landscapes of human breast and colorectal cancers.

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Fältnamn	Indikatorer	Metadata
000		04297naa a2200973 4500
001		oai:DiVA.org:uu-13011
003		SwePub
008		080120s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130112 URI
024	7	a https://doi.org/10.1126/science.11457202 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Wood, Laura D4 aut
245	1 0	a The genomic landscapes of human breast and colorectal cancers.
264	1	b American Association for the Advancement of Science (AAAS),c 2007
338		a print2 rdacarrier
520		a Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.
653		a Animals
653		a Breast Neoplasms/*genetics/metabolism
653		a Cell Line
653		a Chromosome Mapping
653		a Colorectal Neoplasms/*genetics/metabolism
653		a Computational Biology
653		a DNA; Neoplasm
653		a Databases; Genetic
653		a Genes; Neoplasm
653		a Genome; Human
653		a Humans
653		a Metabolic Networks and Pathways/genetics
653		a Mice
653		a Mutation
653		a Neoplasm Proteins/genetics/metabolism
653		a Sequence Analysis; DNA
653		a MEDICINE
653		a MEDICIN
700	1	a Parsons, D Williams4 aut
700	1	a Jones, Siân4 aut
700	1	a Lin, Jimmy4 aut
700	1	a Sjöblom, Tobiasu Uppsala universitet,Institutionen för genetik och patologi,Sjöblom4 aut0 (Swepub:uu)tobisjob
700	1	a Leary, Rebecca J4 aut
700	1	a Shen, Dong4 aut
700	1	a Boca, Simina M4 aut
700	1	a Barber, Thomas4 aut
700	1	a Ptak, Janine4 aut
700	1	a Silliman, Natalie4 aut
700	1	a Szabo, Steve4 aut
700	1	a Dezso, Zoltan4 aut
700	1	a Ustyanksky, Vadim4 aut
700	1	a Nikolskaya, Tatiana4 aut
700	1	a Nikolsky, Yuri4 aut
700	1	a Karchin, Rachel4 aut
700	1	a Wilson, Paul A4 aut
700	1	a Kaminker, Joshua S4 aut
700	1	a Zhang, Zemin4 aut
700	1	a Croshaw, Randal4 aut
700	1	a Willis, Joseph4 aut
700	1	a Dawson, Dawn4 aut
700	1	a Shipitsin, Michail4 aut
700	1	a Willson, James K V4 aut
700	1	a Sukumar, Saraswati4 aut
700	1	a Polyak, Kornelia4 aut
700	1	a Park, Ben Ho4 aut
700	1	a Pethiyagoda, Charit L4 aut
700	1	a Pant, P V Krishna4 aut
700	1	a Ballinger, Dennis G4 aut
700	1	a Sparks, Andrew B4 aut
700	1	a Hartigan, James4 aut
700	1	a Smith, Douglas R4 aut
700	1	a Suh, Erick4 aut
700	1	a Papadopoulos, Nickolas4 aut
700	1	a Buckhaults, Phillip4 aut
700	1	a Markowitz, Sanford D4 aut
700	1	a Parmigiani, Giovanni4 aut
700	1	a Kinzler, Kenneth W4 aut
700	1	a Velculescu, Victor E4 aut
700	1	a Vogelstein, Bert4 aut
710	2	a Uppsala universitetb Institutionen för genetik och patologi4 org
773	0	t Scienced : American Association for the Advancement of Science (AAAS)g 318:5853, s. 1108-1113q 318:5853<1108-1113x 0036-8075x 1095-9203
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17932254&dopt=Citation
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13011
856	4 8	u https://doi.org/10.1126/science.1145720

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Av författaren/redakt...: Wood, Laura D; Parsons, D Willi ...; Jones, Siân; Lin, Jimmy; Sjöblom, Tobias; Leary, Rebecca J; visa fler...; Shen, Dong; Boca, Simina M; Barber, Thomas; Ptak, Janine; Silliman, Natali ...; Szabo, Steve; Dezso, Zoltan; Ustyanksky, Vadi ...; Nikolskaya, Tati ...; Nikolsky, Yuri; Karchin, Rachel; Wilson, Paul A; Kaminker, Joshua ...; Zhang, Zemin; Croshaw, Randal; Willis, Joseph; Dawson, Dawn; Shipitsin, Micha ...; Willson, James K ...; Sukumar, Saraswa ...; Polyak, Kornelia; Park, Ben Ho; Pethiyagoda, Cha ...; Pant, P V Krishn ...; Ballinger, Denni ...; Sparks, Andrew B; Hartigan, James; Smith, Douglas R; Suh, Erick; Papadopoulos, Ni ...; Buckhaults, Phil ...; Markowitz, Sanfo ...; Parmigiani, Giov ...; Kinzler, Kenneth ...; Velculescu, Vict ...; Vogelstein, Bert; visa färre...

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Av lärosätet: Uppsala universitet

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