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Cardiovascular even...
Cardiovascular events after ischemic stroke in young adults: A prospective follow-up study
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Aarnio, K. (author)
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Siegerink, B. (author)
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Pirinen, J. (author)
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Sinisalo, J. (author)
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Lehto, M. (author)
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Haapaniemi, E. (author)
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Nave, A. H. (author)
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Kaste, M. (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Putaala, J. (author)
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(creator_code:org_t)
- 2016-04-20
- 2016
- English.
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In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 86:20, s. 1872-1879
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objectives:To study the long-term risk of recurrent cardiac, arterial, and venous events in young stroke patients, and whether these risks differed between etiologic subgroups.Methods:The study population comprised 970 patients aged 15-49 years from the Helsinki Young Stroke Registry (HYSR) who had an ischemic stroke in 1994-2007. We obtained follow-up data until 2012 from the Finnish Care Register and Statistics Finland. Cumulative 15-year risks were analyzed with life tables, whereas relative risks and corresponding confidence intervals (CI) were based on hazard ratios (HR) from Cox regression analyses.Results:There were 283 (29.2%) patients with a cardiovascular event during the median follow-up of 10.1 years (range 0.1-18.0). Cumulative 15-year risk for venous events was 3.9%. Cumulative 15-year incidence rate for composite vascular events was 34.0 (95% CI 30.1-38.2) per 1,000 person-years. When adjusted for age and sex, patients with an index stroke caused by high-risk sources of cardioembolism had the highest HR for any subsequent cardiovascular events (3.7; 95% CI 2.6-5.4), whereas the large-artery atherosclerosis group had the highest HR (2.7; 95% CI 1.6-4.6) for recurrent stroke compared with patients with stroke of undetermined etiology.Conclusions:The risk for future cardiovascular events after ischemic stroke in young adults remains high for years after the index stroke, in particular when the index stroke is caused by high-risk sources of cardioembolism or large-artery atherosclerosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- HOSPITAL DISCHARGE REGISTER
- RECURRENT VASCULAR EVENTS
- LONG-TERM
- PROGNOSIS
- ATHEROSCLEROTIC DISEASE
- VENOUS THROMBOEMBOLISM
- RISK
- POPULATION
- DEATH
- AGE
- CLASSIFICATION
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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- By the author/editor
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Aarnio, K.
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Siegerink, B.
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Pirinen, J.
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Sinisalo, J.
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Lehto, M.
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Haapaniemi, E.
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show more...
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Nave, A. H.
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Kaste, M.
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Tatlisumak, Turg ...
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Putaala, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg