Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure.

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Fältnamn	Indikatorer	Metadata
000		05213naa a2200529 4500
001		oai:DiVA.org:umu-106582
003		SwePub
008		150721s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1065822 URI
024	7	a https://doi.org/10.1016/j.jbiomech.2008.03.0262 DOI
040		a (SwePub)umu
041		a engb engb -1
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Julkunen, Petrou Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland4 aut
245	1 0	a Stress-relaxation of human patellar articular cartilage in unconfined compression :b prediction of mechanical response by tissue composition and structure.
264	1	b Elsevier,c 2008
338		a print2 rdacarrier
520		a Mechanical properties of articular cartilage are controlled by tissue composition and structure. Cartilage function is sensitively altered during tissue degeneration, in osteoarthritis (OA). However, mechanical properties of the tissue cannot be determined non-invasively. In the present study, we evaluate the feasibility to predict, without mechanical testing, the stress-relaxation response of human articular cartilage under unconfined compression. This is carried out by combining microscopic and biochemical analyses with composition-based mathematical modeling. Cartilage samples from five cadaver patellae were mechanically tested under unconfined compression. Depth-dependent collagen content and fibril orientation, as well as proteoglycan and water content were derived by combining Fourier transform infrared imaging, biochemical analyses and polarized light microscopy. Finite element models were constructed for each sample in unconfined compression geometry. First, composition-based fibril-reinforced poroviscoelastic swelling models, including composition and structure obtained from microscopical and biochemical analyses were fitted to experimental stress-relaxation responses of three samples. Subsequently, optimized values of model constants, as well as compositional and structural parameters were implemented in the models of two additional samples to validate the optimization. Theoretical stress-relaxation curves agreed with the experimental tests (R=0.95-0.99). Using the optimized values of mechanical parameters, as well as composition and structure of additional samples, we were able to predict their mechanical behavior in unconfined compression, without mechanical testing (R=0.98). Our results suggest that specific information on tissue composition and structure might enable assessment of cartilage mechanics without mechanical testing.
520		a
650	7	a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653		a Articular cartilage
653		a finite element analysis
653		a quantitative microscopy
653		a collagen content
653		a fixed charge density
653		a proteoglycans
653		a water fraction
653		a unconfined compression
653		a biomechanics
653		a biomekanik
653		a cell research
653		a cellforskning
700	1	a Wilson, Wouteru Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands4 aut
700	1	a Jurvelin, Jukkau Department of Physics, University of Kuopio, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland4 aut
700	1	a Rieppo, Jarnou Department of Biomedicine, Anatomy, University of Kuopio, Kuopio, FinlandDepartment of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland4 aut
700	1	a Qu, Cheng-Juan,d 1967-u Department of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)chqu0007
700	1	a Lammi, Mikko,d 1961-u Department of Biosciences, Applied Biotechnology, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)mila0077
700	1	a Korhonen, Ramiu Department of Physics, University of Kuopio, Kuopio, Finland; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada4 aut
710	2	a Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finlandb Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands4 org
773	0	t Journal of Biomechanicsd : Elsevierg 41:9, s. 1978-86q 41:9<1978-86x 0021-9290x 1873-2380
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106582
856	4 8	u https://doi.org/10.1016/j.jbiomech.2008.03.026

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Av författaren/redakt...: Julkunen, Petro; Wilson, Wouter; Jurvelin, Jukka; Rieppo, Jarno; Qu, Cheng-Juan, ...; Lammi, Mikko, 19 ...; visa fler...; Korhonen, Rami; visa färre...

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