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Genetic Predisposit...
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
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- van Zuydam, Natalie R. (author)
- Uppsala University,University of Dundee,University of Oxford,Univ Dundee, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Cardiovasc & Diabet Med, Sch Med, Dundee, Scotland.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.
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- Ladenvall, Claes (author)
- Lund Univ, Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, Malmö, Sweden.
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- Voight, Benjamin F. (author)
- Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA.;Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA.
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show more...
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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- Fernandez-Tajes, Juan (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.
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- Rayner, N. William (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, England.
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- Robertson, Neil R. (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.
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- Mahajan, Anubha (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.
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- Vlachopoulou, Efthymia (author)
- Univ Helsinki, Transplantat Lab, Haartman Inst, Helsinki, Finland.
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- Goel, Anuj (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Div Cardiovasc Med, Oxford, England.
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Kleber, Marcus E. (author)
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- Nelson, Christopher P. (author)
- Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.
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- Kwee, Lydia Coulter (author)
- Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.
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- Esko, Tonu (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Mihailov, Evelin (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Magi, Reedik (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Milani, Lili (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Fischer, Krista (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
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- Kanoni, Stavroula (author)
- Queen Mary Univ London, Ctr Genom Hlth, London, England.;Queen Mary Univ London, William Harvey Res Inst, Barts & London Med Sch, London, England.
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- Kumar, Jitender (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Amity Univ Uttar Pradesh, Amity Inst Biotechnol, Ctr Computat Biol & Bioinformat, Noida, India.
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- Song, Ci (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,NHLBI, Framingham Heart Study, NIH, Framingham, MA USA.;NHLBI, Populat Sci Branch, NIH, Framingham, MA USA.
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- Hartiala, Jaana A. (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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- Perola, Markus (author)
- Univ Helsinki, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland. Heidelberg Univ, Med Fac Mannheim, Dept Med Nephrol Hypertensiol Rheumatol Endocrino, Mannheim, Germany.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Natl Inst Hlth & Welf, Helsinki, Finland.
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- Gieger, Christian (author)
- German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, Clin Cooperat Grp Type 2 Diabet, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.
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- Peters, Annette (author)
- German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.
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Qu, Liming (author)
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- Willems, Sara M. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Doney, Alex S. F. (author)
- Univ Dundee, Div Mol & Clin Med, Sch Med, Dundee, Scotland.
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- Morris, Andrew D. (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.;Hlth Data Res UK, London, England.
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- Zheng, Yan (author)
- Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai, Peoples R China.
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- Sesti, Giorgio (author)
- Magna Graecia Univ Catanzaro, Catanzaro, Italy.
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- Hu, Frank B. (author)
- Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Qi, Lu (author)
- Univ Penn, Cardiovasc Inst, Perelman Sch Med, Philadelphia, PA 19104 USA.;Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.
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- Laakso, Markku (author)
- Univ Eastern Finland, Inst Clin Med, Fac Hlth Sci, Internal Med, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.
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- Thorsteinsdottir, Unnur (author)
- Univ Iceland deCODE Genet, Fac Med, Reykjavik, Iceland.
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- Grallert, Harald (author)
- German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, Clin Cooperat Grp Type 2 Diabet, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Inst Epidemiol, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Clin Cooperat Grp Nutrigen & Type 2 Diabet, Neuherberg, Germany.
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- van Duijn, Cornelia (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Reilly, Muredach P. (author)
- Univ Penn, Cardiovasc Inst, Perelman Sch Med, Philadelphia, PA 19104 USA.
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
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- Deloukas, Panos (author)
- Queen Mary Univ London, William Harvey Res Inst, Barts & London Med Sch, London, England.;King Abdulaziz Univ, Princess Al Jawhara Brahim Ctr Excellence Res Her, Jeddah, Saudi Arabia.
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- Kathiresan, Sek (author)
- Harvard Med Sch, Boston, MA 02115 USA.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Div Cardiol, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.
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- Metspalu, Andres (author)
- Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Tartu, Inst Cell & Mol Biol, Tartu, Estonia.
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- Shah, Svati H. (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC 27710 USA.;Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.
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- Sinisalo, Juha (author)
- Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.;Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
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- Salomaa, Veikko (author)
- Natl Inst Hlth & Welf, Helsinki, Finland.
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- Hamsten, Anders (author)
- Karolinska Institutet
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- Samani, Nilesh J. (author)
- Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.
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- Maerz, Winfried (author)
- Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany.;Med Univ Graz, Clin Inst, Med & Chem Lab Diagnost, Graz, Austria.
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- Hazen, Stanley L. (author)
- Cleveland Clin, Lerner Res Inst, Heart & Vasc Inst, Cleveland, OH 44106 USA.
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- Watkins, Hugh (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Div Cardiovasc Med, Oxford, England.
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- Saleheen, Danish (author)
- Univ Penn, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.;Ctr Noncommunicable Dis, Karachi, Pakistan.
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- Morris, Andrew P. (author)
- Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Manchester, Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England.
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- Colhoun, Helen M. (author)
- Univ Edinburgh, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;NHS Fife, Publ Hlth, Kirkcaldy, Fife, Scotland.
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, Malmö, Sweden.
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- McCarthy, Mark I. (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Oxford Univ Hosp NHS Fdn Trust, John Radcliffe Hosp, Oxford NIHR Biomed Res Ctr, Oxford, England.
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- Palmer, Colin N. A. (author)
- Univ Dundee, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Cardiovasc & Diabet Med, Sch Med, Dundee, Scotland.,University of Dundee
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(creator_code:org_t)
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et al
- Lippincott Williams & Wilkins, 2020
- 2020
- English.
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In: Circulation. - : Lippincott Williams & Wilkins. - 2574-8300. ; 13:6, s. 640-648
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Abstract
Subject headings
Close
- BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- blood pressure
- coronary artery disease
- diabetes mellitus
- genome-wide association study
- risk factors
- blood pressure
- coronary artery disease
- diabetes mellitus
- genome-wide association study
- risk factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van Zuydam, Nata ...
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Ladenvall, Claes
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Voight, Benjamin ...
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Strawbridge, Ron ...
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Fernandez-Tajes, ...
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Rayner, N. Willi ...
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show more...
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Robertson, Neil ...
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Mahajan, Anubha
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Vlachopoulou, Ef ...
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Goel, Anuj
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Kleber, Marcus E ...
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Nelson, Christop ...
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Kwee, Lydia Coul ...
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Esko, Tonu
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Mihailov, Evelin
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Magi, Reedik
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Milani, Lili
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Fischer, Krista
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Kanoni, Stavroul ...
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Kumar, Jitender
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Song, Ci
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Hartiala, Jaana ...
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Pedersen, Nancy ...
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Perola, Markus
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Gieger, Christia ...
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Peters, Annette
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Qu, Liming
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Willems, Sara M.
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Doney, Alex S. F ...
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Morris, Andrew D ...
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Zheng, Yan
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Sesti, Giorgio
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Hu, Frank B.
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Qi, Lu
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Laakso, Markku
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Thorsteinsdottir ...
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Grallert, Harald
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van Duijn, Corne ...
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Reilly, Muredach ...
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Ingelsson, Erik, ...
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Deloukas, Panos
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Kathiresan, Sek
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Metspalu, Andres
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Shah, Svati H.
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Sinisalo, Juha
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Salomaa, Veikko
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Hamsten, Anders
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Samani, Nilesh J ...
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Maerz, Winfried
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Hazen, Stanley L ...
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Watkins, Hugh
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Saleheen, Danish
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Morris, Andrew P ...
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Colhoun, Helen M ...
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Groop, Leif
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McCarthy, Mark I ...
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Palmer, Colin N. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet