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WFRF:(Rensen Patrick C. N.)
 

Search: WFRF:(Rensen Patrick C. N.) > Thermogenic adipocy...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003585naa a2200553 4500
001oai:DiVA.org:umu-134812
003SwePub
008170530s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1348122 URI
0247 a https://doi.org/10.1038/ncomms150102 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bartelt, Alexander4 aut
2451 0a Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
264 c 2017-04-19
264 1b NATURE PUBLISHING GROUP,c 2017
338 a electronic2 rdacarrier
520 a Brown and beige adipocytes combust nutrients for thermogenesis and through their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice. However, whether the activation of thermogenic adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL) is unknown. Here, we report a reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to increased HDL levels in APOE(star)3-Leiden. CETP mice. Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic changes in mouse and human HDL. Furthermore, thermogenic stimulation promotes HDL-cholesterol clearance and increases macrophage-to-faeces reverse cholesterol transport in mice. Mechanistically, we show that intravascular lipolysis by adipocyte lipoprotein lipase and hepatic uptake of HDL by scavenger receptor B-I are the driving forces of HDL-cholesterol disposal in liver. Our findings corroborate the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properties via increased systemic cholesterol flux through the HDL compartment.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng
7001 a John, Clara4 aut
7001 a Schaltenberg, Nicola4 aut
7001 a Berbee, Jimmy F. P.4 aut
7001 a Worthmann, Anna4 aut
7001 a Cherradi, M. Lisa4 aut
7001 a Schlein, Christian4 aut
7001 a Piepenburg, Julia4 aut
7001 a Boon, Mariette R.4 aut
7001 a Rinninger, Franz4 aut
7001 a Heine, Markus4 aut
7001 a Toedter, Klaus4 aut
7001 a Niemeier, Andreas4 aut
7001 a Nilsson, Stefan K.u Umeå universitet,Fysiologisk kemi,Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany4 aut0 (Swepub:umu)nist6501
7001 a Fischer, Markus4 aut
7001 a Wijers, Sander L.4 aut
7001 a Lichtenbelt, Wouter van Marken4 aut
7001 a Scheja, Ludger4 aut
7001 a Rensen, Patrick C. N.4 aut
7001 a Heeren, Joerg4 aut
7102 a Umeå universitetb Fysiologisk kemi4 org
7730 t Nature Communicationsd : NATURE PUBLISHING GROUPg 8q 8x 2041-1723
8564 u https://doi.org/10.1038/ncomms15010y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1103160/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/ncomms15010.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134812
8564 8u https://doi.org/10.1038/ncomms15010

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