Characteristics and health risks of the inhalable fraction of metal additive manufacturing powders

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Fältnamn	Indikatorer	Metadata
000		04537naa a2200481 4500
001		oai:DiVA.org:oru-112113
003		SwePub
008		240305s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1121132 URI
024	7	a https://doi.org/10.1002/nano.2023001882 DOI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Alijagic, Andi,d 1992-u Örebro universitet,Institutionen för naturvetenskap och teknik,School of Medical Sciences Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Man-Technology-Environment research center (MTM)4 aut0 (Swepub:oru)aiac
245	1 0	a Characteristics and health risks of the inhalable fraction of metal additive manufacturing powders
264	1	b Wiley-VCH Verlagsgesellschaft,c 2024
338		a print2 rdacarrier
520		a Metal additive manufacturing (AM) is gaining traction but raises worker health concerns due to micron-sized powders, including fine inhalable particles. This study explored particle and surface characteristics, electrochemical properties, metal release in artificial lysosomal fluid (ALF), and potential toxicity of virgin and sieved virgin Fe-based powders, stainless steel (316L), Fe, and two tooling steels. Virgin particles ranged in size from 1 to 100μm, while sieved particles were within the respirable size range (<5–10μm). Surface oxide composition differed from bulk composition. The Fe powder showed low corrosion resistance and high metal release due to a lack of protective surface oxide. Sieved particles of 316L, Fe, and one tooling steel released more metals into ALF than virgin particles, with the opposite was observed for the other tooling steel. Sieved particles had no notable impact on cell viability or micronuclei formation in human bronchial epithelial cells. Inflammatory response in human macrophages was generally low, except for the Fe powder and one tooling steel, which induced increased interleukin-8 (IL-8/CXCL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL-2) secretion. This study underscores distinctions between virgin and sieved Fe-based powders and suggests relatively low acute toxicity.
650	7	a NATURVETENSKAPx Geovetenskap och miljövetenskapx Annan geovetenskap och miljövetenskap0 (SwePub)105992 hsv//swe
650	7	a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Other Earth and Related Environmental Sciences0 (SwePub)105992 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653		a AM manufacturing
653		a exposure
653		a genotoxicity
653		a inflammation
653		a inhalable metallic powders
653		a particle dissolution
653		a Biology
653		a Biologi
700	1	a Wang, Xuyingu KTH Royal Institute of Technology, Division of Surface and Corrosion Science, Stockholm, Sweden4 aut
700	1	a Vallabani, Naga Vera Srikanthu Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden4 aut
700	1	a Melin, Pelleu Swerim, Kista, Sweden4 aut
700	1	a Särndahl, Eva,d 1963-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)4 aut0 (Swepub:oru)easl
700	1	a Karlsson, Hanna L.u Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden4 aut
700	1	a Odnevall, Ingeru KTH Royal Institute of Technology, Division of Surface and Corrosion Science, Stockholm, Sweden; AIMES – Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet and KTH Royal Institute of Technology, Stockholm, Sweden; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden4 aut
710	2	a Örebro universitetb Institutionen för naturvetenskap och teknik4 org
773	0	t Nano Selectd : Wiley-VCH Verlagsgesellschaftg 5:4q 5:4x 2688-4011
856	4	u https://doi.org/10.1002/nano.202300188y Fulltext
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-112113
856	4 8	u https://doi.org/10.1002/nano.202300188

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NATURAL SCIENCES: NATURAL SCIENCES; and Earth and Relate ...; and Other Earth and ...

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