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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005830naa a2200505 4500
001oai:DiVA.org:oru-63695
003SwePub
008171222s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-636952 URI
0247 a https://doi.org/10.1096/fj.14-2501672 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bondia-Pons, Isabelu VTT Technical Research Centre of Finland, Espoo, Finland; Department of Food Science and Physiology, University of Navarra, Pamplona, Spain4 aut
2451 0a Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight :b a Big Mac challenge
264 c 2014-05-20
264 1b Wiley,c 2014
338 a print2 rdacarrier
500 a Funding agencies:EU 222720 277713Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (SyMMyS) 250114Finnish Foundation for Cardiovascular ResearchDiabetes Research FoundationHelsinki University Central Hospital Research FundsAcademy of Finland grant 266286Carlos III Health Institute of the Spanish Ministry of Health
520 a Postprandial responses to food are complex, involving both genetic and environmental factors. We studied postprandial responses to a Big Mac meal challenge in monozygotic co-twins highly discordant for body weight. This unique design allows assessment of the contribution of obesity, independent of genetic liability. Comprehensive metabolic profiling using 3 analytical platforms was applied to fasting and postprandial serum samples from 16 healthy monozygotic twin pairs discordant for weight (body mass index difference >3 kg/m(2)). Nine concordant monozygotic pairs were examined as control pairs. Fecal samples were analyzed to assess diversity of the major bacterial groups by using 5 different validated bacterial group specific denaturing gradient gel electrophoresis methods. No differences in fecal bacterial diversity were detected when comparing co-twins discordant for weight (ANOVA, P<0.05). We found that within-pair similarity is a dominant factor in the metabolic postprandial response, independent of acquired obesity. Branched chain amino acids were increased in heavier as compared with leaner co-twins in the fasting state, but their levels converged postprandially (paired t tests, FDR q<0.05). We also found that specific bacterial groups were associated with postprandial changes of specific metabolites. Our findings underline important roles of genetic and early life factors in the regulation of postprandial metabolite levels.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a bile acids
653 a metabolomics
653 a obesity
7001 a Maukonen, Johannau VTT Technical Research Centre of Finland, Espoo, Finland4 aut
7001 a Mattila, Ismou VTT Technical Research Centre of Finland, Espoo, Finland4 aut
7001 a Rissanen, Ailau Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland4 aut
7001 a Saarela, Mariau VTT Technical Research Centre of Finland, Espoo, Finland4 aut
7001 a Kaprio, Jaakkou Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland4 aut
7001 a Hakkarainen, Anttiu Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland4 aut
7001 a Lundbom, Jesperu Department of Radiology, Hospital District of Helsinki and Uusimaa (HUS) Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland4 aut
7001 a Lundbom, Ninau Department of Radiology, Hospital District of Helsinki and Uusimaa (HUS) Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland4 aut
7001 a Hyötyläinen, Tuulia,d 1971-u Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark4 aut0 (Swepub:oru)tihn
7001 a Pietiläinen, Kirsi H.u Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland4 aut
7001 a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark4 aut0 (Swepub:oru)moc
7102 a VTT Technical Research Centre of Finland, Espoo, Finland; Department of Food Science and Physiology, University of Navarra, Pamplona, Spainb VTT Technical Research Centre of Finland, Espoo, Finland4 org
7730 t The FASEB Journald : Wileyg 28:9, s. 4169-4179q 28:9<4169-4179x 0892-6638x 1530-6860
8564 u https://europepmc.org/articles/pmc5395738
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63695
8564 8u https://doi.org/10.1096/fj.14-250167

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