WFRF:(Sahlgren C)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02062naa a2200301 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1929235 | |
| 003 | SwePub | |
| 008 | 240811s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19292352 URI |
| 024 | 7 | a https://doi.org/10.1083/jcb.2006020092 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Chapman, G4 aut |
| 245 | 1 0 | a High levels of Notch signaling down-regulate Numb and Numblike |
| 264 | c 2006-11-20 | |
| 264 | 1 | b Rockefeller University Press,c 2006 |
| 520 | a Inhibition of Notch signaling by Numb is critical for many cell fate decisions. In this study, we demonstrate a more complex relationship between Notch and the two vertebrate Numb homologues Numb and Numblike. Although Numb and Numblike at low levels of Notch signaling negatively regulated Notch, high levels of Notch signaling conversely led to a reduction of Numb and Numblike protein levels in cultured cells and in the developing chick central nervous system. The Notch intracellular domain but not the canonical Notch downstream proteins Hes 1 and Hey 1 caused a reduction of Numb and Numblike. The Notch-mediated reduction of Numblike required the PEST domain in the Numblike protein and was blocked by the proteasome inhibitor MG132. Collectively, these observations reveal a reciprocal negative regulation between Notch and Numb/Numblike, which may be of relevance for stabilizing asymmetric cell fate switches and for tumor development. | |
| 700 | 1 | a Liu, LN4 aut |
| 700 | 1 | a Sahlgren, C4 aut |
| 700 | 1 | a Dahlqvist, C4 aut |
| 700 | 1 | a Lenclahl, U4 aut |
| 773 | 0 | t The Journal of cell biologyd : Rockefeller University Pressg 175:4, s. 535-540q 175:4<535-540x 0021-9525x 1540-8140 |
| 856 | 4 | u http://jcb.rupress.org/content/175/4/535.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1929235 |
| 856 | 4 8 | u https://doi.org/10.1083/jcb.200602009 |
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- Chapman, G
- Liu, LN
- Sahlgren, C
- Dahlqvist, C
- Lenclahl, U
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