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Nonallelic transvec...
Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development
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- Sandhu, Kuljeet Singh (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Shi, Chengxi (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Sjölinder, Mikael (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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show more...
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- Zhao, Zhihu (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Gondor, Anita (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Liu, Liang (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Tiwari, Vijay K. (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Guibert, Sylvain (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Emilsson, Lina (author)
- Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Imreh, Marta P. (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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- Ohlsson, Rolf (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för fysiologi och utvecklingsbiologi
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(creator_code:org_t)
- 2009-11-16
- 2009
- English.
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In: Genes & Development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 23:22, s. 2598-2603
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http://genesdev.cshl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Transvection
- imprinting
- epigenetics
- replication timing
- H19 ICR
- Biology
- Biologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Sandhu, Kuljeet ...
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Shi, Chengxi
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Sjölinder, Mikae ...
-
Zhao, Zhihu
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Gondor, Anita
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Liu, Liang
-
show more...
-
Tiwari, Vijay K.
-
Guibert, Sylvain
-
Emilsson, Lina
-
Imreh, Marta P.
-
Ohlsson, Rolf
-
show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Genes & Developm ...
- By the university
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Uppsala University
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Karolinska Institutet