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Increased cell-medi...
Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis.
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- Franzen-Röhl, Elisabeth (author)
- Karolinska Institutet
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- Schepis, Danika (author)
- Karolinska Institutet
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Lagrelius, Maria (author)
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Franck, Kristina (author)
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Jones, Petra (author)
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- Liljeqvist, Jan-Åke, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Aurelius, Elisabeth (author)
- Karolinska Institutet
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- Kärre, Klas (author)
- Karolinska Institutet
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- Berg, Louise (author)
- Karolinska Institutet
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Gaines, Hans (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: Clinical and vaccine immunology : CVI. - 1556-679X. ; 18:4, s. 655-60
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https://doi.org/10.1...
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Abstract
Subject headings
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- The clinical picture of herpes simplex virus type 2 (HSV-2) infection includes genital blisters and less frequently meningitis, and some individuals suffer from recurrent episodes of these manifestations. We hypothesized that adaptive and/or innate immune functional deficiencies may be a major contributing factor in susceptibility to recurrent HSV-2 meningitis. Ten patients with recurrent HSV-2 meningitis were studied during clinical remission. For comparison, 10 patients with recurrent genital HSV infections as well as 21 HSV-seropositive and 19 HSV-seronegative healthy blood donors were included. HSV-specific T cell blasting and cytokine secretion were evaluated in whole blood cultures. HSV-2-induced NK cell gamma interferon production, dendritic cell Toll-like receptor (TLR) expression, and TLR agonist-induced alpha interferon secretion were analyzed. Patients with recurrent HSV-2 meningitis had elevated T cell blasting and Th1 and Th2 cytokine production in response to HSV antigens compared to those of patients with recurrent genital infections. A somewhat increased NK cell response, increased dendritic cell expression of TLR3 and -9, and increased TLR-induced alpha interferon responses were also noted. Contrary to our expectation, recurrent HSV-2 meningitis patients have increased HSV-specific adaptive and innate immune responses, raising the possibility of immune-mediated pathology in the development of recurrent HSV2 meningitis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Adult
- Cytokines
- secretion
- Dendritic Cells
- immunology
- Female
- Gene Expression
- Herpes Simplex
- immunology
- Herpesvirus 2
- Human
- immunology
- Humans
- Immunity
- Cellular
- Killer Cells
- Natural
- immunology
- Male
- Meningitis
- Viral
- immunology
- Middle Aged
- Recurrence
- T-Lymphocytes
- immunology
- Toll-Like Receptors
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Franzen-Röhl, El ...
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Schepis, Danika
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Lagrelius, Maria
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Franck, Kristina
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Jones, Petra
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Liljeqvist, Jan- ...
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show more...
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Bergström, Tomas ...
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Aurelius, Elisab ...
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Kärre, Klas
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Berg, Louise
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Gaines, Hans
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Clinical and vac ...
- By the university
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University of Gothenburg
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Karolinska Institutet