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Internalization of ...
Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis
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- Thorek, Daniel L J (author)
- Memorial Sloan-Kettering Cancer Center
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- Watson, Philip A. (author)
- Memorial Sloan-Kettering Cancer Center
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- Lee, Sang Gyu (author)
- Memorial Sloan-Kettering Cancer Center
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- Ku, Anson T. (author)
- Memorial Sloan-Kettering Cancer Center
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- Bournazos, Stylianos (author)
- Rockefeller University
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- Braun, Katharina (author)
- Ruhr-University Bochum
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- Kim, Kwanghee (author)
- Memorial Sloan-Kettering Cancer Center
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- Sjostrom, Kjell (author)
- Innovagen AB
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- Doran, Michael G. (author)
- Memorial Sloan-Kettering Cancer Center
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- Lamminmaki, Urpo (author)
- University of Turku
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- Santos, Elmer (author)
- Memorial Sloan-Kettering Cancer Center
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- Veach, Darren (author)
- Weill Cornell Medical College
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- Turkekul, Mesruh (author)
- Memorial Sloan-Kettering Cancer Center
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- Casey, Emily (author)
- Memorial Sloan-Kettering Cancer Center
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- Lewis, Jason S. (author)
- Memorial Sloan-Kettering Cancer Center
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- Abou, Diane S. (author)
- Johns Hopkins University School of Medicine
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- Van Voss, Marise R H (author)
- University Medical Center Utrecht
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- Scardino, Peter T. (author)
- Weill Cornell Medical College
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- Strand, Sven Erik (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Alpaugh, Mary L. (author)
- Rowan University
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- Scher, Howard I. (author)
- Weill Cornell Medical College
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- Lilja, Hans (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Larson, Steven M. (author)
- Weill Cornell Medical College
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- Ulmert, David (author)
- Lund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2016
- 2016
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 8:367
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells. Fluorescent and radio conjugates of 11B6, an antibody targeting free hK2, are internalized and noninvasively report AR pathway activity in metastatic and genetically engineered models of cancer development and treatment. Uptake is mediated by a mechanism involving the neonatal Fc receptor. Humanized 11B6, which has undergone toxicological tests in nonhuman primates, has the potential to improve patient management in these cancers. Furthermore, cellspecific SATA uptake may have a broader use for molecularly guided diagnosis and therapy in other cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Thorek, Daniel L ...
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Watson, Philip A ...
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Lee, Sang Gyu
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Ku, Anson T.
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Bournazos, Styli ...
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Braun, Katharina
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show more...
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Kim, Kwanghee
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Sjostrom, Kjell
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Doran, Michael G ...
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Lamminmaki, Urpo
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Santos, Elmer
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Veach, Darren
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Turkekul, Mesruh
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Casey, Emily
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Lewis, Jason S.
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Abou, Diane S.
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Van Voss, Marise ...
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Scardino, Peter ...
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Strand, Sven Eri ...
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Alpaugh, Mary L.
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Scher, Howard I.
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Lilja, Hans
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Larson, Steven M ...
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Ulmert, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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Lund University