WFRF:(Silberberg G.)
Search: WFRF:(Silberberg G.) > (2020-2024) > Ongoing movement co...
- 4 of 11
- Previous record
- Next record
- To hitlist
Ongoing movement controls sensory integration in the dorsolateral striatum
-
- de la Torre-Martinez, R (author)
- Karolinska Institutet
-
- Ketzef, M (author)
- Karolinska Institutet
-
- Silberberg, G (author)
- Karolinska Institutet
- (creator_code:org_t)
- 2023-02-22
- 2023
- English.
- In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 1004-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions. In the neocortex, sensory responses are affected by motor activity, however, it is not known whether such sensorimotor interactions occur in the striatum and how they are shaped by dopamine. To determine the impact of motor activity on striatal sensory processing, we performed in vivo whole-cell recordings in the DLS of awake mice during the presentation of tactile stimuli. Striatal medium spiny neurons (MSNs) were activated by both whisker stimulation and spontaneous whisking, however, their responses to whisker deflection during ongoing whisking were attenuated. Dopamine depletion reduced the representation of whisking in direct-pathway MSNs, but not in those of the indirect-pathway. Furthermore, dopamine depletion impaired the discrimination between ipsilateral and contralateral sensory stimulation in both direct and indirect pathway MSNs. Our results show that whisking affects sensory responses in DLS and that striatal representation of both processes is dopamine- and cell type-dependent.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Nature communications (Search for host publication in LIBRIS)
To the university's database
- 4 of 11
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- de la Torre-Mart ...
- Ketzef, M
- Silberberg, G
- Articles in the publication
- Nature communica ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
