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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
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| 001 | oai:prod.swepub.kib.ki.se:142655749 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-157800 | |
| 009 | oai:gup.ub.gu.se/273609 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1426557492 URI |
| 024 | 7 | a https://doi.org/10.1038/s42003-018-0155-y2 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1578002 URI |
| 024 | 7 | a https://gup.ub.gu.se/publication/2736092 URI |
| 040 | a (SwePub)kid (SwePub)umud (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
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| 100 | 1 | a de Jong, S4 aut |
| 245 | 1 0 | a Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder |
| 264 | c 2018-10-08 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 520 | a Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 700 | 1 | a Diniz, MJAu Karolinska Institutet4 aut |
| 700 | 1 | a Saloma, A4 aut |
| 700 | 1 | a Gadelha, A4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
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| 700 | 1 | a Breen, G4 aut |
| 700 | 1 | a Wray, NR4 aut |
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| 700 | 1 | a Trzaskowski, M4 aut |
| 700 | 1 | a Byrne, EM4 aut |
| 700 | 1 | a Abdellaoui, Au Karolinska Institutet4 aut |
| 700 | 1 | a Adams, MJ4 aut |
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| 700 | 1 | a Lichtenstein, Pu Karolinska Institutet4 aut |
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| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Communications biologyd : Springer Science and Business Media LLCg 1, s. 163-q 1<163-x 2399-3642 |
| 856 | 4 | u https://www.nature.com/articles/s42003-018-0155-y.pdf |
| 856 | 4 | u https://doi.org/10.1038/s42003-018-0155-yy Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1301715/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142655749 |
| 856 | 4 8 | u https://doi.org/10.1038/s42003-018-0155-y |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157800 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/273609 |
Hitta mer i SwePub
- Av författaren/redakt...
- de Jong, S
- Diniz, MJA
- Saloma, A
- Gadelha, A
- Landén, Mikael, ...
- Ota, VK
- visa fler...
- Noto, C
- Curtis, C
- Newhouse, SJ
- Patel, H
- Hall, LS
- O'Reilly, PF
- Belangero, SI
- Adolfsson, Rolf
- Breen, G
- Wray, NR
- Ripke, S
- Mattheisen, M
- Trzaskowski, M
- Byrne, EM
- Abdellaoui, A
- Adams, MJ
- Agerbo, E
- Air, TM
- Andlauer, TFM
- Bacanu, SA
- Baekvad-Hansen, ...
- Beekman, ATF
- Bigdeli, TB
- Binder, EB
- Blackwood, DHR
- Bryois, J
- Buttenschon, HN
- Bybjerg-Grauholm ...
- Cai, N
- Castelao, E
- Christensen, JH
- Clarke, TK
- Coleman, JRI
- Colodro-Conde, L
- Couvy-Duchesne, ...
- Craddock, N
- Crawford, GE
- Davies, G
- Deary, IJ
- Degenhardt, F
- Derks, EM
- Direk, N
- Dolan, CV
- Dunn, EC
- Eley, TC
- Escott-Price, V
- Kiadeh, FFH
- Finucane, HK
- Forstner, AJ
- Frank, J
- Gaspar, HA
- Gill, M
- Goes, FS
- Gordon, SD
- Grove, J
- Hansen, CS
- Hansen, TF
- Herms, S
- Hickie, IB
- Hoffmann, P
- Homuth, G
- Horn, C
- Hottenga, JJ
- Hougaard, DM
- Ising, M
- Jansen, R
- Jones, I
- Jones, LA
- Jorgenson, E
- Knowles, JA
- Kohane, IS
- Kraft, J
- Kretzschmar, WW
- Krogh, J
- Kutalik, Z
- Li, YH
- Lind, PA
- MacIntyre, DJ
- MacKinnon, DF
- Maier, RM
- Maier, W
- Marchini, J
- Mbarek, H
- McGrath, P
- McGuffin, P
- Medland, SE
- Mehta, D
- Middeldorp, CM
- Mihailov, E
- Milaneschi, Y
- Milani, L
- Mondimore, FM
- Montgomery, GW
- Mostafavi, S
- Mullins, N
- Nauck, M
- Ng, B
- Nivard, MG
- Nyholt, DR
- Oskarsson, H
- Owen, MJ
- Painter, JN
- Pedersen, CB
- Pedersen, MG
- Peterson, RE
- Pettersson, E
- Peyrot, WJ
- Pistis, G
- Posthuma, D
- Quiroz, JA
- Qvist, P
- Rice, JP
- Riley, BP
- Rivera, M
- Mirza, SS
- Schoevers, R
- Schulte, EC
- Shen, L
- Shyn, SI
- Sigurdsson, E
- Sinnamon, GCB
- Smit, JH
- Smith, DJ
- Stefansson, H
- Steinberg, S
- Streit, F
- Strohmaier, J
- Tansey, KE
- Teismann, H
- Teumer, A
- Thompson, W
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