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  • Müller, Thomas R.Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden (författare)

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-212217
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212217URI
  • https://doi.org/10.1126/scitranslmed.adg9452DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153247906URI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in individuals with various immunodeficiencies. Given the increased antibody evasion properties of emerging SARS-CoV-2 subvariants, it is necessary to assess whether other components of adaptive immunity generate resilient and protective responses against infection. We assessed T cell responses in 279 individuals, covering five different immunodeficiencies and healthy controls, before and after booster mRNA vaccination, as well as after Omicron infection in a subset of patients. We observed robust and persistent Omicron-reactive T cell responses that increased markedly upon booster vaccination and correlated directly with antibody titers across all patient groups. Poor vaccination responsiveness in immunocompromised or elderly individuals was effectively counteracted by the administration of additional vaccine doses. Functionally, Omicron-reactive T cell responses exhibited a pronounced cytotoxic profile and signs of longevity, characterized by CD45RA+ effector memory subpopulations with stem cell-like properties and increased proliferative capacity. Regardless of underlying immunodeficiency, booster-vaccinated and Omicron-infected individuals appeared protected against severe disease and exhibited enhanced and diversified T cell responses against conserved and Omicron-specific epitopes. Our findings indicate that T cells retain the ability to generate highly functional responses against newly emerging variants, even after repeated antigen exposure and a robust immunological imprint from ancestral SARS-CoV-2 mRNA vaccination.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sekine, TakuyaDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Trubach, DaryaDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark (författare)
  • Niessl, JuliaDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Chen, PuranDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Bergman, PeterKarolinska Institutet (författare)
  • Blennow, OlaDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Transplantation, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden (författare)
  • Hansson, LottaKarolinska Institutet (författare)
  • Mielke, StephanKarolinska Institutet (författare)
  • Nowak, PiotrUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden (författare)
  • Vesterbacka, JanDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden (författare)
  • Akber, MiraDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Olofsson, AnnaDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Amaya Hernandez, Susana PatriciaDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark (författare)
  • Gao, YuDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Cai, CurtisKarolinska Institutet (författare)
  • Söderdahl, GunnarDepartment of Transplantation, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden (författare)
  • Smith, C I EdvardDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Laboratory Medicine, Biomolecular and Cellular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Stockholm, Sweden (författare)
  • Österborg, AndersKarolinska Institutet (författare)
  • Loré, KarinDepartment of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (författare)
  • Sällberg Chen, MargaretDepartment of Dental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Ljungman, PerDepartment of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Medicine Huddinge, Hematology, Karolinska Institutet, Stockholm, Sweden (författare)
  • Ljunggren, Hans-GustafDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Karlsson, Annika C.Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Karolinska University Laboratory, Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden (författare)
  • Saini, Sunil KumarDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark (författare)
  • Aleman, SooKarolinska Institutet (författare)
  • Buggert, MarcusKarolinska Institutet (författare)
  • Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, SwedenDepartment of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Science Translational Medicine15:704, s. eadg9452-1946-62341946-6242

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