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Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes : The EPIC-InterAct Case-Cohort Study
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- Forouhi, Nita G. (författare)
- University of Cambridge
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- Imamura, Fumiaki (författare)
- University of Cambridge
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- Sharp, Stephen J. (författare)
- University of Cambridge
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Koulman, Albert (författare)
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- Schulze, Matthias B. (författare)
- German Institute of Human Nutrition
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- Zheng, Jusheng (författare)
- University of Cambridge
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- Ye, Zheng (författare)
- University of Cambridge
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- Sluijs, Ivonne (författare)
- University Medical Center Utrecht
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Guevara, Marcela (författare)
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- Maria Huerta, Jose (författare)
- Murcia Regional Health Council
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- Kroeger, Janine (författare)
- German Institute of Human Nutrition
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Wang, Laura Yun (författare)
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Summerhill, Keith (författare)
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Griffin, Julian L. (författare)
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- Feskens, Edith J. M. (författare)
- Wageningen University
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Affret, Aurelie (författare)
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Amiano, Pilar (författare)
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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Dow, Courtney (författare)
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Fagherazzi, Guy (författare)
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- Franks, Paul W. (författare)
- Umeå University,Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Gonzalez, Carlos (författare)
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Key, Timothy J. (författare)
- University of Oxford
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- Khaw, Kay Tee (författare)
- University of Cambridge
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- Kuehn, Tilman (författare)
- German Cancer Research Centre
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- Mortensen, Lotte Maxild (författare)
- Aarhus University
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Overvad, Kim (författare)
- Aalborg University Hospital
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- Pala, Valeria (författare)
- Istituto Nazionale dei Tumori
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Ramon Quiros, J. (författare)
- Public Health Directorate
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Rodriguez-Barranco, Miguel (författare)
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- Rolandsson, Olov (författare)
- Umeå universitet,Allmänmedicin
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- Sacerdote, Carlotta (författare)
- Human Genetics Foundation (HuGeF)
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Scalbert, Augustin (författare)
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Slimani, Nadia (författare)
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Spijkerman, Annemieke M. W. (författare)
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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Tormo, Maria-Jose (författare)
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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van der A, Daphne L. (författare)
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- van der Schouw, Yvonne T. (författare)
- University Medical Center Utrecht
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- Langenberg, Claudia (författare)
- University of Cambridge
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- Riboli, Elio (författare)
- Imperial College London
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- Wareham, Nicholas J. (författare)
- University of Cambridge
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(creator_code:org_t)
- 2016-07-19
- 2016
- Engelska.
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Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 13:7
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations.Methods and Findings Plasma phospholipid PUFAs were measured by gas chromatography among 12,132 incident T2D cases and 15,919 subcohort participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study across eight European countries. Country-specific hazard ratios (HRs) were estimated using Prentice-weighted Cox regression and pooled by random-effects meta-analysis. We also systematically reviewed published prospective studies on circulating PUFAs and T2D risk and pooled the quantitative evidence for comparison with results from EPIC-InterAct. In EPIC-InterAct, among long-chain n-3 PUFAs, a-linolenic acid (ALA) was inversely associated with T2D (HR per standard deviation [SD] 0.93; 95% CI 0.88-0.98), but eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were not significantly associated. Among n-6 PUFAs, linoleic acid (LA) (0.80; 95% CI 0.77-0.83) and eicosadienoic acid (EDA) (0.89; 95% CI 0.85-0.94) were inversely related, and arachidonic acid (AA) was not significantly associated, while significant positive associations were observed with.-linolenic acid (GLA), dihomo-GLA, docosatetraenoic acid (DTA), and docosapentaenoic acid (n6-DPA), with HRs between 1.13 to 1.46 per SD. These findings from EPIC-InterAct were broadly similar to comparative findings from summary estimates from up to nine studies including between 71 to 2,499 T2D cases. Limitations included potential residual confounding and the inability to distinguish between dietary and metabolic influences on plasma phospholipid PUFAs.Conclusions These large-scale findings suggest an important inverse association of circulating plant-origin n-3 PUFA (ALA) but no convincing association of marine-derived n3 PUFAs (EPA and DHA) with T2D. Moreover, they highlight that the most abundant n6-PUFA (LA) is inversely associated with T2D. The detection of associations with previously less well-investigated PUFAs points to the importance of considering individual fatty acids rather than focusing on fatty acid class.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Forouhi, Nita G.
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Imamura, Fumiaki
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Sharp, Stephen J ...
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Koulman, Albert
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Schulze, Matthia ...
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Zheng, Jusheng
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visa fler...
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Ye, Zheng
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Sluijs, Ivonne
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Guevara, Marcela
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Maria Huerta, Jo ...
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Kroeger, Janine
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Wang, Laura Yun
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Summerhill, Keit ...
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Griffin, Julian ...
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Feskens, Edith J ...
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Affret, Aurelie
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Amiano, Pilar
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Boeing, Heiner
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Dow, Courtney
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Fagherazzi, Guy
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Franks, Paul W.
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Gonzalez, Carlos
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Kaaks, Rudolf
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Key, Timothy J.
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Khaw, Kay Tee
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Kuehn, Tilman
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Mortensen, Lotte ...
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Nilsson, Peter M ...
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Overvad, Kim
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Pala, Valeria
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Palli, Domenico
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Panico, Salvator ...
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Ramon Quiros, J.
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Rodriguez-Barran ...
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Rolandsson, Olov
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Sacerdote, Carlo ...
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Scalbert, August ...
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Slimani, Nadia
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Spijkerman, Anne ...
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Tjonneland, Anne
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Tormo, Maria-Jos ...
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Tumino, Rosario
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van der A, Daphn ...
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van der Schouw, ...
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Langenberg, Clau ...
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Riboli, Elio
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Wareham, Nichola ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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PLoS Medicine
- Av lärosätet
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Umeå universitet
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Lunds universitet