Sökning: WFRF:(Sundström Poromaa Inger 1964 )
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White matter micros...
White matter microstructure and volume correlates of premenstrual dysphoric disorder
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- Gu, Xuan (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för neurovetenskap
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- Dubol, Manon (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab
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- Stiernman, Louise (författare)
- Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, Umeå, Sweden.
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- Wikström, Johan, 1964- (författare)
- Uppsala universitet,Radiologi
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- Hahn, Andreas (författare)
- Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria,Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria.
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- Lanzenberger, Rupert (författare)
- Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria,Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria.
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- Epperson, C. Neill (författare)
- Department of Psychiatry, University of Colorado School of Medicine, USA,Univ Colorado, Sch Med, Dept Psychiat, Boulder, CO 80309 USA.
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- Bixo, Marie (författare)
- Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, Umeå, Sweden.
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- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa
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- Comasco, Erika, 1982- (författare)
- Uppsala universitet,Reproduktiv hälsa,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2022-02-23
- 2022
- Engelska.
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Ingår i: Journal of Psychiatry & Neuroscience. - : Canadian Medical Association. - 1180-4882 .- 1488-2434. ; 47:1, s. E67-E76
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized by psychological and physical symptoms. Differences in white matter have been associated with affective and anxiety disorders, which share some symptoms with PMDD. However, whether white matter structure differs between the brains of individuals with PMDD and healthy controls is not known, nor is its relation to symptom severity.METHODS: We performed tract-based spatial statistics and voxel-based morphometry analyses of diffusion tensor imaging metrics and white matter volume, using 2 neuroimaging data sets (n = 67 and n = 131) and a combined whole-brain and region-of-interest approach. We performed correlation analyses to investigate the relationship between regions with different white matter microstructure and volume and PMDD symptom severity.RESULTS: We found greater fractional anisotropy in the left uncinate fasciculus (d = 0.69) in individuals with PMDD compared to controls. Moreover, the volume of the right uncinate fasciculus was higher in individuals with PMDD compared to controls (d = 0.40). As well, the severity of premenstrual depression was positively correlated with fractional anisotropy in the right superior longitudinal fasciculus (r = 0.35).LIMITATIONS: It is challenging to interpret group differences in diffusion tensor imaging metrics in terms of their underlying biophysical properties. The small size of the control group in the diffusion tensor imaging study may have prevented effects of interest from being detected.CONCLUSION: The findings of the present study provide evidence of differential cerebral white matter structure associated with PMDD and its symptoms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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Gu, Xuan
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Dubol, Manon
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Stiernman, Louis ...
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Wikström, Johan, ...
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Hahn, Andreas
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Lanzenberger, Ru ...
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Epperson, C. Nei ...
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Bixo, Marie
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Sundström Poroma ...
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Comasco, Erika, ...
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Umeå universitet
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