Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination

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Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination

Cagigi, Alberto (author): Karolinska Institutet

Yu, Meng (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Österberg, Björn (author): Karolinska Institutet

Svensson, Julia (author): Karolinska Institutet

Falck-Jones, Sara (author): Karolinska Institutet

Vangeti, Sindhu (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Åhlberg, Eric (author): Karolinska Institutet

Azizmohammadi, Lida (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Warnqvist, Anna (author): Karolinska Institutet

Falck-Jones, Ryan (author): Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden

Gubisch, Pia C. (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Ödemis, Mert (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Ghafoor, Farangies (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Eisele, Mona (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Lenart, Klara (author): Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Bell, Max (author): Karolinska Institutet

Johansson, Niclas (author): Division of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital Solna, Stockholm, Sweden

Albert, Jan (author): Karolinska Institutet

Sälde, Jörgen (author): Närakut SLSO, Karolinska University Hospital Solna, Stockholm, Sweden

Pettie, Deleah D. (author): Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States

Murphy, Michael P. (author): Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States

Carter, Lauren (author): Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States

King, Neil P. (author): Department of Biochemistry, University of Washington, WA, Seattle, United States; Institute for Protein Design, University of Washington, WA, Seattle, United States

Ols, Sebastian (author): Karolinska Institutet

Normark, Johan (author): Umeå universitet,Immunologi/immunkemi

Ahlm, Clas, 1956- (author): Umeå universitet,Immunologi/immunkemi

Forsell, Mattias N. (author): Umeå universitet,Immunologi/immunkemi

Färnert, Anna (author): Karolinska Institutet

Loré, Karin (author): Karolinska Institutet

Smed-Sörensen, Anna (author): Karolinska Institutet

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2021-11-22
2021
English.
In: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 6:22

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); http://insight.jci.o...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Understanding the presence and durability of antibodies against SARS-CoV-2 in the airways is required to provide insights into the ability of individuals to neutralize the virus locally and prevent viral spread. Here, we longitudinally assessed both systemic and airway immune responses upon SARS-CoV-2 infection in a clinically well-characterized cohort of 147 infected individuals representing the full spectrum of COVID-19 severity, from asymptomatic infection to fatal disease. In addition, we evaluated how SARS-CoV-2 vaccination influenced the antibody responses in a subset of these individuals during convalescence as compared with naive individuals. Not only systemic but also airway antibody responses correlated with the degree of COVID-19 disease severity. However, although systemic IgG levels were durable for up to 8 months, airway IgG and IgA declined significantly within 3 months. After vaccination, there was an increase in both systemic and airway antibodies, in particular IgG, often exceeding the levels found during acute disease. In contrast, naive individuals showed low airway antibodies after vaccination. In the former COVID-19 patients, airway antibody levels were significantly elevated after the boost vaccination, highlighting the importance of prime and boost vaccinations for previously infected individuals to obtain optimal mucosal protection.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

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By the university: Umeå University; Karolinska Institutet

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Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination

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