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HLA and KIR Associa...
HLA and KIR Associations of Cervical Neoplasia
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- Pettersson-Kymmer, Ulrika (author)
- Umeå University,Umeå universitet,Farmakologi,Näringsforskning
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- Hanson, Aimee L (author)
- Princess Alexandra Hospital,University of Queensland
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- Madeleine, Margaret M (author)
- Fred Hutchinson Cancer Research Center,Queensland University of Technology,University of Melbourne,Murdoch Children's Research Institute
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- Wang, Sophia S (author)
- City of Hope National Medical Center
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Schwartz, Stephen M (author)
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- Newell, Felicity (author)
- Queensland University of Technology
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Pettersson-Kymmer, Ulrika (author)
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
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- Tiews, Sven (author)
- MVZ Labor für Cytopathologie Dr. Steinberg GmbH
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- Steinberg, Winfried (author)
- MVZ Labor für Cytopathologie Dr. Steinberg GmbH
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- Rader, Janet S (author)
- Medical College of Wisconsin
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- Castro, Felipe (author)
- German Cancer Research Centre
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- Safaeian, Mahboobeh (author)
- National Cancer Institute, NCI
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- Franco, Eduardo L (author)
- McGill University
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- Coutlée, François (author)
- University Of Montreal Health Center (CRCHUM)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Centre for Bone and Arthritis Research,Institutionen för medicin,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Cortes, Adrian (author)
- University of Queensland
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Marshall, Mhairi (author)
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- Mukhopadhyay, Pamela (author)
- University of Queensland
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- Cremin, Katie (author)
- University of Queensland
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- Johnson, Lisa G (author)
- Fred Hutchinson Cancer Research Center
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Garland, Suzanne M (author)
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- Tabrizi, Sepehr N (author)
- Murdoch Children's Research Institute,University of Melbourne
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- Wentzensen, Nicolas (author)
- National Cancer Institute, NCI
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- Sitas, Freddy (author)
- Cancer Council New South Wales,University of New South Wales,University of Sydney
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- Trimble, Cornelia (author)
- Johns Hopkins University
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- Little, Julian (author)
- University of Ottawa
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- Cruickshank, Maggie (author)
- University of Aberdeen
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- Frazer, Ian H (author)
- University of Queensland,Princess Alexandra Hospital
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- Hildesheim, Allan (author)
- National Cancer Institute, NCI
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- Brown, Matthew A (author)
- Queensland University of Technology
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- Duncan, Emma L (author)
- Queensland University of Technology
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Sun, YingPu (author)
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- Leo, Paul J (author)
- Queensland University of Technology
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- Bao, Xiao (author)
- First Affiliated Hospital of Zhengzhou University,Queensland University of Technology
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- Sun, Ying Pu (author)
- First Affiliated Hospital of Zhengzhou University
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(creator_code:org_t)
- 2018-08-07
- 2018
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 218:12, s. 2006-2015
- Related links:
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Background: Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognised by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of particular HLA-KIR combinations would increase cervical neoplasia risk.Methods: Here, we used HLA and KIR dosages imputed from SNP genotype data from 2,143 cervical neoplasia cases and 13,858 healthy controls of European decent.Results: Four novel HLA alleles were identified in association with cervical neoplasia: HLA-DRB3*9901 (OR=1.24, P=2.49×10-9), HLA-DRB5*0101 (OR=1.29, P=2.26×10-8), HLA-DRB5*9901 (OR=0.77, P=1.90×10-9) and HLA-DRB3*0301 (OR=0.63, P=4.06×10-5), due to their linkage disequilibrium with known cervical neoplasia-associated HLA-DRB1 alleles. We also found homozygosity of HLA-C1 group alleles is a protective factor for HPV16-related cervical neoplasia (C1/C1, OR=0.79, P=0.005). This protective association was restricted to carriers of either KIR2DL2 (OR=0.67, P=0.00045) or KIR2DS2 (OR=0.69, P=0.0006).Conclusions: Our findings suggest that HLA-C1 group alleles play a role in protecting against HPV16-related cervical neoplasia, mainly through a KIR-mediated mechanism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Cervical neoplasia; human leukocyte antigens (HLA)
- killer immunoglobulin-like receptors (KIRs)
- HPV16-related cervical neoplasia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pettersson-Kymme ...
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Hanson, Aimee L
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Madeleine, Marga ...
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Wang, Sophia S
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Schwartz, Stephe ...
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Newell, Felicity
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show more...
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Hemminki, Kari
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Tiews, Sven
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Steinberg, Winfr ...
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Rader, Janet S
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Castro, Felipe
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Safaeian, Mahboo ...
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Franco, Eduardo ...
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Coutlée, Françoi ...
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Ohlsson, Claes, ...
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Cortes, Adrian
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Marshall, Mhairi
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Mukhopadhyay, Pa ...
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Cremin, Katie
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Johnson, Lisa G
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Garland, Suzanne ...
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Tabrizi, Sepehr ...
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Wentzensen, Nico ...
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Sitas, Freddy
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Trimble, Corneli ...
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Little, Julian
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Cruickshank, Mag ...
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Frazer, Ian H
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Hildesheim, Alla ...
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Brown, Matthew A
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Duncan, Emma L
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Sun, YingPu
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Leo, Paul J
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Bao, Xiao
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Sun, Ying Pu
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Umeå University
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Lund University
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University of Gothenburg