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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007022naa a2200889 4500
001oai:DiVA.org:umu-151134
003SwePub
008180828s2018 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:05e4559f-ae73-4504-898d-69a15b8424a4
009oai:gup.ub.gu.se/273945
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1511342 URI
0247 a https://doi.org/10.1093/infdis/jiy4832 DOI
0247 a https://lup.lub.lu.se/record/05e4559f-ae73-4504-898d-69a15b8424a42 URI
0247 a https://gup.ub.gu.se/publication/2739452 URI
040 a (SwePub)umud (SwePub)lud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pettersson-Kymmer, Ulrikau Umeå University,Umeå universitet,Farmakologi,Näringsforskning4 aut0 (Swepub:umu)ulpe0007
2451 0a HLA and KIR Associations of Cervical Neoplasia
264 c 2018-08-07
264 1b Oxford University Press,c 2018
338 a print2 rdacarrier
520 a Background: Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognised by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of particular HLA-KIR combinations would increase cervical neoplasia risk.Methods: Here, we used HLA and KIR dosages imputed from SNP genotype data from 2,143 cervical neoplasia cases and 13,858 healthy controls of European decent.Results: Four novel HLA alleles were identified in association with cervical neoplasia: HLA-DRB3*9901 (OR=1.24, P=2.49×10-9), HLA-DRB5*0101 (OR=1.29, P=2.26×10-8), HLA-DRB5*9901 (OR=0.77, P=1.90×10-9) and HLA-DRB3*0301 (OR=0.63, P=4.06×10-5), due to their linkage disequilibrium with known cervical neoplasia-associated HLA-DRB1 alleles. We also found homozygosity of HLA-C1 group alleles is a protective factor for HPV16-related cervical neoplasia (C1/C1, OR=0.79, P=0.005). This protective association was restricted to carriers of either KIR2DL2 (OR=0.67, P=0.00045) or KIR2DS2 (OR=0.69, P=0.0006).Conclusions: Our findings suggest that HLA-C1 group alleles play a role in protecting against HPV16-related cervical neoplasia, mainly through a KIR-mediated mechanism.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653 a Cervical neoplasia; human leukocyte antigens (HLA)
653 a killer immunoglobulin-like receptors (KIRs)
653 a HPV16-related cervical neoplasia
7001 a Hanson, Aimee Lu Princess Alexandra Hospital,University of Queensland4 aut
7001 a Madeleine, Margaret Mu Fred Hutchinson Cancer Research Center,Queensland University of Technology,University of Melbourne,Murdoch Children's Research Institute4 aut
7001 a Wang, Sophia Su City of Hope National Medical Center4 aut
7001 a Schwartz, Stephen M4 aut
7001 a Newell, Felicityu Queensland University of Technology4 aut
7001 a Pettersson-Kymmer, Ulrika4 aut
7001 a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre4 aut0 (Swepub:lu)med-khk
7001 a Tiews, Svenu MVZ Labor für Cytopathologie Dr. Steinberg GmbH4 aut
7001 a Steinberg, Winfriedu MVZ Labor für Cytopathologie Dr. Steinberg GmbH4 aut
7001 a Rader, Janet Su Medical College of Wisconsin4 aut
7001 a Castro, Felipeu German Cancer Research Centre4 aut
7001 a Safaeian, Mahboobehu National Cancer Institute, NCI4 aut
7001 a Franco, Eduardo Lu McGill University4 aut
7001 a Coutlée, Françoisu University Of Montreal Health Center (CRCHUM)4 aut
7001 a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,University of Gothenburg,Centre for Bone and Arthritis Research,Institutionen för medicin,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl
7001 a Cortes, Adrianu University of Queensland4 aut
7001 a Marshall, Mhairi4 aut
7001 a Mukhopadhyay, Pamelau University of Queensland4 aut
7001 a Cremin, Katieu University of Queensland4 aut
7001 a Johnson, Lisa Gu Fred Hutchinson Cancer Research Center4 aut
7001 a Garland, Suzanne M4 aut
7001 a Tabrizi, Sepehr Nu Murdoch Children's Research Institute,University of Melbourne4 aut
7001 a Wentzensen, Nicolasu National Cancer Institute, NCI4 aut
7001 a Sitas, Freddyu Cancer Council New South Wales,University of New South Wales,University of Sydney4 aut
7001 a Trimble, Corneliau Johns Hopkins University4 aut
7001 a Little, Julianu University of Ottawa4 aut
7001 a Cruickshank, Maggieu University of Aberdeen4 aut
7001 a Frazer, Ian Hu University of Queensland,Princess Alexandra Hospital4 aut
7001 a Hildesheim, Allanu National Cancer Institute, NCI4 aut
7001 a Brown, Matthew Au Queensland University of Technology4 aut
7001 a Duncan, Emma Lu Queensland University of Technology4 aut
7001 a Sun, YingPu4 aut
7001 a Leo, Paul Ju Queensland University of Technology4 aut
7001 a Bao, Xiaou First Affiliated Hospital of Zhengzhou University,Queensland University of Technology4 aut
7001 a Sun, Ying Puu First Affiliated Hospital of Zhengzhou University4 aut
7102 a Umeå universitetb Farmakologi4 org
7730 t Journal of Infectious Diseasesd : Oxford University Pressg 218:12, s. 2006-2015q 218:12<2006-2015x 0022-1899x 1537-6613
8564 u https://academic.oup.com/jid/article-pdf/218/12/2006/26362864/jiy483.pdf
8564 u http://dx.doi.org/10.1093/infdis/jiy483y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-151134
8564 8u https://doi.org/10.1093/infdis/jiy483
8564 8u https://lup.lub.lu.se/record/05e4559f-ae73-4504-898d-69a15b8424a4
8564 8u https://gup.ub.gu.se/publication/273945

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