A brief history of nearly EV-erything - The rise and rise of extracellular vesicles

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Fältnamn	Indikatorer	Metadata
000		03199naa a2200625 4500
001		oai:gup.ub.gu.se/312742
003		SwePub
008		240528s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3127422 URI
024	7	a https://doi.org/10.1002/jev2.121442 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Couch, Y.4 aut
245	1 0	a A brief history of nearly EV-erything - The rise and rise of extracellular vesicles
264		c 2021-12-17
264	1	b Wiley,c 2021
520		a Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell-to-cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to take stock and look back on how the field started, and has since exploded into its current state. Here we review the early experiments, summarise key findings that have propelled the field, describe the growth of an organised EV community, discuss the current state of the field, and identify key challenges that need to be addressed.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a ectosome
653		a exosome
653		a extracellular vesicle
653		a microparticle
653		a microvesicle
653		a cell-derived exosomes
653		a virus-like particles
653		a trypsin-like-enzyme
653		a transferrin receptor
653		a membrane-vesicles
653		a platelet microparticles
653		a reticulocyte maturation
653		a multivesicular body
653		a proteomic analysis
653		a human
653		a neutrophils
653		a Cell Biology
700	1	a Buzas, E. I.4 aut
700	1	a Vizio, D. D.4 aut
700	1	a Gho, Y. S.4 aut
700	1	a Harrison, P.4 aut
700	1	a Hill, A. F.4 aut
700	1	a Lötvall, Jan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Krefting Research Centre,Institute of Medicine4 aut0 (Swepub:gu)xlotja
700	1	a Raposo, G.4 aut
700	1	a Stahl, P. D.4 aut
700	1	a Thery, C.4 aut
700	1	a Witwer, K. W.4 aut
700	1	a Carter, D. R. F.4 aut
710	2	a Göteborgs universitetb Institutionen för medicin4 org
773	0	t Journal of Extracellular Vesiclesd : Wileyg 10:14q 10:14x 2001-3078
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jev2.12144
856	4 8	u https://gup.ub.gu.se/publication/312742
856	4 8	u https://doi.org/10.1002/jev2.12144

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Av författaren/redakt...: Couch, Y.; Buzas, E. I.; Vizio, D. D.; Gho, Y. S.; Harrison, P.; Hill, A. F.; visa fler...; Lötvall, Jan, 19 ...; Raposo, G.; Stahl, P. D.; Thery, C.; Witwer, K. W.; Carter, D. R. F.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

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Av lärosätet: Göteborgs universitet

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