Search: WFRF:(Timpson Nicholas J)
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Variations in the G...
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
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Chen, Wei-Min (author)
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Erdos, Michael R (author)
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Jackson, Anne U (author)
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show more...
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Saxena, Richa (author)
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Sanna, Serena (author)
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Silver, Kristi D (author)
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Timpson, Nicholas J (author)
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Hansen, Torben (author)
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Orrù, Marco (author)
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Grazia Piras, Maria (author)
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Bonnycastle, Lori L (author)
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Willer, Cristen J (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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Shen, Haiqing (author)
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Kuusisto, Johanna (author)
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Ebrahim, Shah (author)
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Sestu, Natascia (author)
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Duren, William L (author)
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Spada, Maria Cristina (author)
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Stringham, Heather M (author)
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Scott, Laura J (author)
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Olla, Nazario (author)
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Swift, Amy J (author)
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Najjar, Samer (author)
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Mitchell, Braxton D (author)
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Lawlor, Debbie A (author)
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Smith, George Davey (author)
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Ben-Shlomo, Yoav (author)
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Andersen, Gitte (author)
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Borch-Johnsen, Knut (author)
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Jørgensen, Torben (author)
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Saramies, Jouko (author)
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Valle, Timo T (author)
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Buchanan, Thomas A (author)
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Shuldiner, Alan R (author)
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Lakatta, Edward (author)
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Bergman, Richard N (author)
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Uda, Manuela (author)
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Tuomilehto, Jaakko (author)
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Pedersen, Oluf (author)
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Cao, Antonio (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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Mohlke, Karen L (author)
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Laakso, Markku (author)
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Schlessinger, David (author)
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Collins, Francis S (author)
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Altshuler, David (author)
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Abecasis, Gonçalo R (author)
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Boehnke, Michael (author)
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Scuteri, Angelo (author)
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Watanabe, Richard M (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Journal of Clinical Investigation. - 0021-9738. ; Jun 2, s. 2620-2628
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose concentrations (P = 3.5 x 10(-7)). This association was further investigated in an additional 18,436 nondiabetic individuals of mixed European descent from 7 different studies. The combined P value for association in these follow-up samples was 6.9 x 10(-26), and combining results from all studies resulted in an overall P value for association of 6.4 x 10(-33). Across these studies, fasting glucose concentrations increased 0.01-0.16 mM with each copy of the major allele, accounting for approximately 1% of the total variation in fasting glucose. The rs563694 SNP is located between the genes glucose-6-phosphatase catalytic subunit 2 (G6PC2) and ATP-binding cassette, subfamily B (MDR/TAP), member 11 (ABCB11). Our results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Chen, Wei-Min
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Erdos, Michael R
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Jackson, Anne U
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Saxena, Richa
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Sanna, Serena
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Silver, Kristi D
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show more...
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Timpson, Nichola ...
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Hansen, Torben
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Orrù, Marco
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Grazia Piras, Ma ...
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Bonnycastle, Lor ...
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Willer, Cristen ...
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Lyssenko, Valeri ...
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Shen, Haiqing
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Kuusisto, Johann ...
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Ebrahim, Shah
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Sestu, Natascia
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Duren, William L
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Spada, Maria Cri ...
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Stringham, Heath ...
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Scott, Laura J
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Olla, Nazario
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Swift, Amy J
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Najjar, Samer
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Mitchell, Braxto ...
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Lawlor, Debbie A
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Smith, George Da ...
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Ben-Shlomo, Yoav
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Andersen, Gitte
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Borch-Johnsen, K ...
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Jørgensen, Torbe ...
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Saramies, Jouko
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Valle, Timo T
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Buchanan, Thomas ...
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Shuldiner, Alan ...
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Lakatta, Edward
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Bergman, Richard ...
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Uda, Manuela
-
Tuomilehto, Jaak ...
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Pedersen, Oluf
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Cao, Antonio
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Groop, Leif
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Mohlke, Karen L
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Laakso, Markku
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Schlessinger, Da ...
-
Collins, Francis ...
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Altshuler, David
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Abecasis, Gonçal ...
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Boehnke, Michael
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Scuteri, Angelo
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Watanabe, Richar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Lund University